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Cat. No.: HY-182721

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Pipinib

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC₅₀ of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma.

For research use only. We do not sell to patients.

CAS No.: 2380013-55-6
Formula: C₁₇H₁₈N₄O₂S
Molecular Weight:342.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pipinib Chemical Structure

CAS No.: 2380013-55-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

All PI4K Isoforms :

In Vitro

Pipinib (0.001-10 μM; 96 h) inhibits Purmorphamine (HY-15108)-induced osteogenesis in C3H10T1/2 cells, with an IC₅₀ of 0.6 μM^[1].
Pipinib (0.01-100 μM; 48 h) inhibits GLI-mediated transcription in Shh-LIGHT2 cells, with an IC₅₀ of 1.7 μM^[1].
Pipinib (0.01-10 μM; 48 h) reduces the Purmorphamine-induced expression of Ptch1 and Gli1 in NIH/3T3 cells, with IC₅₀ values of 3.1 μM and 4.1 μM, respectively^[1].
Pipinib (5 μM; 48 h) reduces PI4P levels in NIH/3T3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:

C3H10T1/2 mesenchymal progenitor cells
Concentration:

0.001, 0.01, 0.1, 1, 10 μM
Incubation Time:

96 h
Result:

Potently inhibited Purmorphamine-induced osteogenesis, with an IC₅₀ of 0.6 μM.

Chemical Information

CAS No. 2380013-55-6
Molecular Weight 342.42
Formula C₁₇H₁₈N₄O₂S
SMILES

O=C(C1=CC=C(NC2=NC(NC(C)C)=NC3=C2SC=C3)C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kremer L, et al. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 2019;58(46):16617-16628. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pipinib

All PI4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

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Pipinib Related Classifications

HY-182721 Related Classifications