2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. PI4K Hedgehog
  4. Pipinib

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma.

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Pipinib

Pipinib Chemical Structure

CAS No. : 2380013-55-6

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Pipinib Related Antibodies

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Description

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma[1].

In Vitro

Pipinib (0.001-10 μM; 96 h) inhibits Purmorphamine (HY-15108)-induced osteogenesis in C3H10T1/2 cells, with an IC50 of 0.6 μM[1].
Pipinib (0.01-100 μM; 48 h) inhibits GLI-mediated transcription in Shh-LIGHT2 cells, with an IC50 of 1.7 μM[1].
Pipinib (0.01-10 μM; 48 h) reduces the Purmorphamine-induced expression of Ptch1 and Gli1 in NIH/3T3 cells, with IC50 values of 3.1 μM and 4.1 μM, respectively[1].
Pipinib (5 μM; 48 h) reduces PI4P levels in NIH/3T3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pipinib Related Antibodies

Cell Differentiation Assay[1]

Cell Line: C3H10T1/2 mesenchymal progenitor cells
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 96 h
Result: Potently inhibited Purmorphamine-induced osteogenesis, with an IC50 of 0.6 μM.
Molecular Weight

342.42

Formula

C17H18N4O2S
CAS No.
SMILES

O=C(C1=CC=C(NC2=NC(NC(C)C)=NC3=C2SC=C3)C=C1)OC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pipinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipinib2380013-55-6PI4KHedgehogPhosphatidylinositol 4 kinasesPI4 kinasesC3H10T1/2 cellsmedulloblastomaHedgehog pathwayGLI-mediated transcriptionbasal cell carcinomaPI4KBphosphatidylinositol 4-kinase IIIbShh-LIGHT2 cellsphosphatidylinositol 4-phosphatePI4PInhibitorinhibitorinhibit

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