2380013-55-6

Pipinib Chemical Structure
2380013-55-6

Chemical Structure

Pipinib

  • CAS No.: 2380013-55-6
  • Formula:C17H18N4O2S
  • Molecular Weight:342.42

InChIKey: VMQMFJKEFGMXOI-UHFFFAOYSA-N

SMILES: O=C(C1=CC=C(NC2=NC(NC(C)C)=NC3=C2SC=C3)C=C1)OC

Biological Activity: Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma[1].

Cat. No. Product Name Purity Description Pricing
HY-182721 		Pipinib Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma.
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