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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
e-selectin
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "e-selectin" in MCE Product Catalog:
5
5 Cited Publications
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A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases .
4
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Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .
4
4 Cited Publications
Cat. No.: HY-U00003
CAS No.: 251994-14-6
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ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.
1
Category:
Polysaccharides Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides
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1
1 Cited Publications
Cat. No.: HY-P990247
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1
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Sialyl Lewis A (SLeA) sodium is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A sodium promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A sodium shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A sodium can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer .
1
Cat. No.: HY-125475
CAS No.: 927881-99-0
Synonyms: GMI-1070
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Rivipansel is a small-molecule glycomimetic pan-selectin antagonist with inhibitory activity against E-selectin and P-selectin. Rivipansel binds tightly to the lectin domain of E-selectin, and selectively blocks the recognition of CD62L by E-selectin without affecting the binding of PSGL-1 to E-selectin. Rivipansel functionally inhibits the adhesion of hematopoietic cells to endothelial cells, and is applicable to research related to sickle cell disease .
Cat. No.: HY-N8903
CAS No.: 222973-44-6
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Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .
Cat. No.: HY-W854385
CAS No.: 92448-22-1
Synonyms: SLeA
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Sialyl Lewis A (SLeA) is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer .
Cat. No.: HY-E70303
CAS No.: 2178088-82-7
Synonyms: FUT6
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Fucosyltransferase 6 is a fucosyltransferase that mediates the expression of the tetrasaccharide Sialyl-Lewis x (sLex, CD15s) on the surface of leukocytes. sLex participates in E-selectin-mediated leukocyte rolling and is related to the migration of leukocytes out of blood vessels .
Cat. No.: HY-P990847
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Cat. No.: HY-106139A
CAS No.: 187269-60-9
Synonyms: TBC-1269Z
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Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects .
Cat. No.: HY-158459
Synonyms: A2G2F2(a1-3) glycan
Cat. No.: HY-106139R
CAS No.: 187269-40-5
Synonyms: TBC-1269 (Standard)
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Bimosiamose (Standard) is the analytical standard of Bimosiamose. This product is intended for research and analytical applications. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .
Cat. No.: HY-158458
Synonyms: A2[3]G1F1(a1-3) glycan
Cat. No.: HY-160072
CAS No.: 1194666-63-1
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Fmoc-NH-PEG2-NHS ester is an intermediate used in the synthesis of E-selectin antagonists [1] .
Cat. No.: HY-P10770
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Cat. No.: HY-P75220
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: E-selectin; ELAM-1; LECAM2; CD63E; SELE
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
