L-Selectin

L-Selectin; CD62L;

L-selectin (CD62L) is a type I transmembrane cell adhesion molecule expressed on most circulating leukocytes, including neutrophils. L-selectin recognizes sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant predominantly N-linked to L-selectin. L-selectin on human neutrophils is itself decorated with sLeX, it can act as a ligand for E-selectin. L-selectin engaged with endothelial-derived ligands initiates neutrophil tethering and rolling behavior along luminal walls of post-capillary venules, constituting the first step of the multi-step adhesion cascade. Blocking the shedding of L-selectin can profoundly alter cell polarity in monocytes entering the subendothelial space^[1].

References:

[1]. Aleksandar Ivetic, et al. A head-to-tail view of L-selectin and its impact on neutrophil behaviour. Cell Tissue Res. 2018 Jan 20;371(3):437–453.

L-Selectin Inhibitors (5)

L-Selectin Related Products (5):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-106139

Bimosiamose	Inhibitor	≥99.0%
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC₅₀s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

HY-P990201

Anti-Mouse L-Selectin/CD62L Antibody (Mel-14)	Inhibitor
Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is an anti-mouse L-Selectin/CD62L IgG2a monoclonal antibody. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can significantly inhibit the migration of T cells and B cells. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can block initial lymphocyte homing. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can be used for researches on inflammation, metabolic and infection conditions such as diabetes and parasitic infections.

HY-P992212

Anti-CD62L Antibody (DREG-200)	Inhibitor
Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).

HY-P991794

Anti-Rat L-selectin Antibody (OX-85)	Inhibitor
Anti-Rat L-selectin Antibody (OX-85) reacts with rat L-selectin (CD62L). Anti-Rat L-selectin Antibody (OX-85) inhibits L-selectin in vivo and in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-P990197

Anti-Mouse MAdCAM-1 Antibody (MECA-367)	Inhibitor
Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1 IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes.

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