2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Pseurotin A

Pseurotin A is a secondary metabolite of Aspergillus and other fungi. Pseurotin A is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50 = 3.6 μM). Pseurotin A inhibits the PCSK9-LDLr interaction. Pseurotin A shows dose-dependent reduction of PCSK9, along with increased LDLR levels in hormone-dependent breast cancer cell lines. Pseurotin A exhibits antitumor activity.

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Pseurotin A

Pseurotin A 構造式

CAS 番号 : 58523-30-1

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Pseurotin A 関連抗体

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製品説明

Pseurotin A is a secondary metabolite of Aspergillus and other fungi. Pseurotin A is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50 = 3.6 μM). Pseurotin A inhibits the PCSK9-LDLr interaction. Pseurotin A shows dose-dependent reduction of PCSK9, along with increased LDLR levels in hormone-dependent breast cancer cell lines. Pseurotin A exhibits antitumor activity[1][2][3].

IC50 & Target

Microbial Metabolite

 

Cellular Effect
Cell Line Type Value Description References
K562 IC50
>10 nM
Compound: 1
Cytotoxicity against human K562 cells
Cytotoxicity against human K562 cells
[PMID: 19179074]
K562 IC50
41 μM
Compound: 5
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 19256529]
Lymphocyte IC50
>10 μM
Compound: 1
Immunosuppressive activity in rat lymphocytes assessed as inhibition of mixed-lymphocyte reaction
Immunosuppressive activity in rat lymphocytes assessed as inhibition of mixed-lymphocyte reaction
[PMID: 19179074]
RAW264.7 IC50
>100 μM
Compound: pseurotin A
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
[PMID: 27976895]
Vero IC50
50 μM
Compound: 22
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
[PMID: 12828470]
体外実験

Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC50 value of 1.2 μM[3].
Pseurotin A (25-100 μM; 72 hours) significantly suppresses the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines[3].
Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner[3].
Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pseurotin A 関連抗体

Cell Viability Assay[3]

Cell Line: BT-474 cells, T47D cells
Concentration: 40-200 μM
Incubation Time: 24-72 hours
Result: Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively).
体内実験

Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)[1]
Dosage: 10 mg/kg
Administration: P.o.; 7X/week, 30 days
Result: Significantly suppressed the growth of BT474 tumors.
分子量

431.44

分子式

C22H25NO8
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C)=C([C@@H](O)[C@@H](O)/C=C\CC)O[C@]12C(N[C@@](OC)(C(C3=CC=CC=C3)=O)[C@@H]2O)=O
Structure Classification
Initial Source

Ascomycetes
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
参考文献
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Pseurotin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pseurotin A58523-30-1Endogenous MetaboliteIgEproductionneuritogenicbreastcellscancerBT-474T47DInhibitorinhibitorinhibit

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製品名:
Pseurotin A
製品番号:
HY-125916
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