8 Results for "

ACh levels

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "ACh levels" in MCE Product Catalog:

Cat. No.: HY-N8376
CAS No.: 20725-03-5
Synonyms: (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .
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Cat. No.: HY-10351A
CAS No.: 184674-99-5
Synonyms: NAD-​299 hydrochloride
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

Robalzotan hydrochloride (NAD-​299 hydrochloride) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system .
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Cat. No.: HY-N0801
CAS No.: 22338-71-2
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .
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Cat. No.: HY-123858
CAS No.: 2002495-17-0
Target:  

nAChR

Research Areas:  

Neurological Disease

VU6001221 is a blood-brain barrier permeable Choline Transporter (CHT) inhibitor (IC50 = 270 nM). VU6001221 increases the likelihood of extracellular choline elevation activating synaptic α7 nicotine ACh receptors. VU6001221 attenuates potassium-induced ACh levels in the prefrontal cortex .
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Cat. No.: HY-10351
CAS No.: 169758-66-1
Synonyms: NAD-​299
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

Robalzotan (NAD-​299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system .
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Cat. No.: HY-19085
CAS No.: 63233-46-5
Target:  

Cholinesterase (ChE)

Research Areas:  

Neurological Disease

KW-6055 is a benzylpyridine derivative with anti-amnesic effects. KW-6055 can increase the level of ACh in the brain cholinergic system and stimulate cholinergic neurons.
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Cat. No.: HY-106385
CAS No.: 869493-21-0
Synonyms: VRX-03011 free base
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

PRX-03140 is a selective, blood-brain-barrier permeable 5-HT4 receptor agonist with a Ki value of 110 nM against rat brain 5-HT4 receptor. PRX-03140 can increase cortical ACh and histamine levels. PRX-03140 can be used in the research of Alzheimer's disease .
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Cat. No.: HY-W754293
CAS No.: 23513-72-6
Synonyms: V0191; DMAE pidolate; DMAE PCA
Target:  

mAChR

Research Areas:  

Neurological Disease

Deanol pidolate (V0191; DMAE pidolate) is an orally active pro-cholinergic agent that improves cognitive symptoms by increasing the release of acetylcholine (Ach) and avoids the typical side effects of cholinesterase inhibitors. Deanol pidolate can alleviate the harmful effects of scopolamine on long-term memory and restore to baseline levels more quickly. Deanol pidolate can be used in research on Alzheimer's disease .
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