169758-66-1
169758-66-1
Chemical Structure
Robalzotan
Synonym(s): NAD-299
- CAS No.: 169758-66-1
- Formula:C18H23FN2O2
- Molecular Weight:318.39
IUPAC Name: (R)-3-(dicyclobutylamino)-8-fluorochromane-5-carboxamide
InChIKey: MQTUXRKNJYPMCG-CYBMUJFWSA-N
SMILES: O=C(C1=C2C[C@@H](N(C3CCC3)C4CCC4)COC2=C(F)C=C1)N
Biological Activity: Robalzotan (NAD-299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system[1][2][3].
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Robalzotan | Robalzotan (NAD-299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system. | |||||||||||||||||||||
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References
- [1]. Arborelius L, et al. The 5-HT(1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur J Pharmacol. 1999 Oct 8;382(2):133-8. [Content Brief]
- [2]. Farde L, et al. PET-Determination of robalzotan (NAD-299) induced 5-HT(1A) receptor occupancy in the monkey brain. Neuropsychopharmacology. 2000 Apr;22(4):422-9. [Content Brief]
- [3]. Hu, Xiao Jing, et al. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat. 2007.
Keywords
