1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Robalzotan

Robalzotan (NAD-​299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system.

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Robalzotan Chemical Structure

Robalzotan Chemical Structure

CAS No. : 169758-66-1

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Description

Robalzotan (NAD-​299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system[1][2][3].

IC50 & Target[1]

5-HT1A Receptor

 

In Vivo

Robalzotan (1-100 µg/kg; i.v.) significantly increases the activity of such neurons at 5 µg/kg in rats, and reverses the acute inhibitory effect of citalopram (HY-121203) (300 µg/kg i.v.) or paroxetine (HY-122272) (100 µg/kg, i.v.) on the activity of 5-HT neurons in the dorsal raphe nucleus in rats[1].
Robalzotan (5, 50 µg/kg; i.v.) increases the firing rate of the 5-HT cells[1].
Robalzotan (2-100 µg/kg; i.v.) occupies 5-HT1A receptors in a dose-dependent in monkeys[2].
Robalzotan (0.3; 1 and 3 µmol/kg s.c) causes a dose-dependent increase of extracellular ACh levels in the rat FC[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

318.39

Formula

C18H23FN2O2

CAS No.
SMILES

O=C(C1=C2C[C@@H](N(C3CCC3)C4CCC4)COC2=C(F)C=C1)N

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Robalzotan
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HY-10351
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