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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
AP2A1
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "AP2A1" in MCE Product Catalog:
Cat. No.: HY-N14035
CAS No.: 90045-23-1
Cat. No.: HY-RS00784
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AP2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00786
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AP2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00787
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AP2M1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2M1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00788
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AP2S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22390
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Ap2m1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ap2m1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28914
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Ap2m1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ap2m1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-161261
SARS-CoV-2-IN-81 (compound 12e) is a potent AAK1 inhibitor with an IC50 value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against SARS-CoV-2. SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection .
Cat. No.: HY-169405
AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC, that inhibits AAK1, HDAC1, and HDAC6 with IC50s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection, suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction .
Cat. No.: HY-RS29524
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designed siRNAs for AP2M1 gene (Green Monkey), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
AP2M1 siRNA-1: 5 nmol (HPLC)
AP2M1 siRNA-2: 5 nmol (HPLC)
AP2M1 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Components
AP2M1 siRNA-1: 5 nmol (HPLC)
AP2M1 siRNA-2: 5 nmol (HPLC)
AP2M1 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Cat. No.: HY-184580
Research Areas:
KMG-732 is a dual-target inhibitor that targets GAK and β-tubulin, with Kd values of 12.0 nM and 19.3 μM, respectively. KMG-732 exhibits broad-spectrum antiproliferative activity in various human cancer cell lines and directly binds to purified tubulin in vitro. KMG-732 reduces the phosphorylation level of AP2M1, induces G2/M phase cell cycle arrest, disrupts the microtubule network, and inhibits cancer cell migration and invasion. KMG-732 shows significant antitumor activity in organoid and in vivo xenograft models. KMG-732 can be used for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
