AAK1/HDACs-IN-1
AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC, that inhibits AAK1, HDAC1, and HDAC6 with IC50s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection, suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction.
For research use only. We do not sell to patients.
- Formula: C21H14N4O2
- Molecular Weight:354.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 5.2 nM (IC50) |
AAK1 15.9 nM (IC50) |
HDAC1 148.6 nM (IC50) |
Chemical Information
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Molecular Weight 354.36
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Formula C21H14N4O2
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SMILES
ONC(C1=CC=C(C=C1)C2=CN=C3NC=C(C3=C2)C#CC4=CN=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AAK1/HDACs-IN-1 Related Classifications
HY-169405 Related Classifications
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