AAK1/HDACs-IN-1
AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC, that inhibits AAK1, HDAC1, and HDAC6 with IC50s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection, suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction.
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- Formel: C21H14N4O2
- Molecular Weight:354.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC6 5.2 nM (IC50) |
AAK1 15.9 nM (IC50) |
HDAC1 148.6 nM (IC50) |
Chemical Information
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Molecular Weight 354.36
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Formel C21H14N4O2
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SMILES
ONC(C1=CC=C(C=C1)C2=CN=C3NC=C(C3=C2)C#CC4=CN=CC=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AAK1/HDACs-IN-1 Related Classifications
HY-169405 Related Classifications
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