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Aconitum carmichaeli

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cyclophilin (1) Drug Derivative (2) Endogenous Metabolite (1) Mitochondrial Metabolism (1) Potassium Channel (1) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (2) Inflammation/Immunology (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0663

Talatisamine	Mitochondrial Metabolism Cyclophilin Potassium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Talatisamine is an orally active cyclophilin D activator isolated from the roots of Aconitum carmichaeli Debx. Talatisamine exerts biological functions by activating cyclophilin D, inhibiting Ca ²⁺-dependent opening of the mitochondrial permeability transition pore (mPTP) (IC₅₀=78 μM), and blocking delayed rectifier K ⁺ channels (IC₅₀=146 μM). Talatisamine possesses both antioxidant and membrane-stabilizing properties, effectively inhibits lipid peroxidation and protects mitochondrial membrane function. Talatisamine exhibits multiple activities including antiarrhythmic, hypotensive, anti-inflammatory, anticancer and neuroprotective effects. Talatisamine finds applications in the research of ischemic diseases, rheumatoid arthritis, inflammation-related diseases and Alzheimer's disease .

HY-106950AR

Fosfructose trisodium (Standard) Diphosphofructose trisodium (Standard); Esafosfan trisodium (Standard); FDP trisodium (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease
Crassicauline A (Standard) is the analytical standard of Crassicauline A. This product is intended for research and analytical applications. Crassicauline A (Crassicaulin A) is a bioactive alkaloid found in roots of Aconitum carmichaeli. Crassicauline A (Crassicaulin A) possesses feeding deterrent activity against T. castaneum adults with an EC50 of 1134.5 ppm .

HY-N3203

Neolinine	Others	Others
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .

HY-N0851

Foresaconitine Vilmorrianine C	Others	Others
Foresaconitine(Vilmorrianine C) is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.

HY-N17886

Karacolidine	Drug Derivative	Others
Karacolidine (compound 9) is an aconitine-type alkaloid. Karacolidine can be found in the lateral root of Aconitum carmichaeli Debx. (Radix Aconiti Lateralis) .

HY-N17839

Senbusine A	Drug Derivative	Others
Senbusine A (compound 4) is a diterpenic alkaloid found in the dried roots of Aconitum carmichaeli from China. Senbusine A acts as an intermediate in the biosynthesis of aconitine .

HY-N9031

Carmichaenine D	Others	Others
Carmichaenine D is a Alkaloids product that can be isolated from the aerial parts of Aconitum carmichaeli. .

HY-N9029

Carmichaenine B	Others	Others
Carmichaenine B is a Alkaloids product that can be isolated from the aerial parts of Aconitum carmichaeli. .

Talatisamine	Alkaloids Structural Classification Pyrrole Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Mitochondrial Metabolism Cyclophilin Potassium Channel
Talatisamine is an orally active cyclophilin D activator isolated from the roots of Aconitum carmichaeli Debx. Talatisamine exerts biological functions by activating cyclophilin D, inhibiting Ca ²⁺-dependent opening of the mitochondrial permeability transition pore (mPTP) (IC₅₀=78 μM), and blocking delayed rectifier K ⁺ channels (IC₅₀=146 μM). Talatisamine possesses both antioxidant and membrane-stabilizing properties, effectively inhibits lipid peroxidation and protects mitochondrial membrane function. Talatisamine exhibits multiple activities including antiarrhythmic, hypotensive, anti-inflammatory, anticancer and neuroprotective effects. Talatisamine finds applications in the research of ischemic diseases, rheumatoid arthritis, inflammation-related diseases and Alzheimer's disease .

Fosfructose trisodium (Standard) Diphosphofructose trisodium (Standard); Esafosfan trisodium (Standard); FDP trisodium (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Crassicauline A (Standard) is the analytical standard of Crassicauline A. This product is intended for research and analytical applications. Crassicauline A (Crassicaulin A) is a bioactive alkaloid found in roots of Aconitum carmichaeli. Crassicauline A (Crassicaulin A) possesses feeding deterrent activity against T. castaneum adults with an EC50 of 1134.5 ppm .

Neolinine	Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Others
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .

Foresaconitine Vilmorrianine C	Alkaloids Pyrrole Alkaloids Classification of Application Fields Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Others
Foresaconitine(Vilmorrianine C) is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.

Karacolidine	Structural Classification Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Drug Derivative
Karacolidine (compound 9) is an aconitine-type alkaloid. Karacolidine can be found in the lateral root of Aconitum carmichaeli Debx. (Radix Aconiti Lateralis) .

Senbusine A	Structural Classification Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Drug Derivative
Senbusine A (compound 4) is a diterpenic alkaloid found in the dried roots of Aconitum carmichaeli from China. Senbusine A acts as an intermediate in the biosynthesis of aconitine .

Carmichaenine D	Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Others
Carmichaenine D is a Alkaloids product that can be isolated from the aerial parts of Aconitum carmichaeli. .

Carmichaenine B	Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Source Classification	Others
Carmichaenine B is a Alkaloids product that can be isolated from the aerial parts of Aconitum carmichaeli. .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Aconitum carmichaeli

Inhibitors & Agonists

NaturalProducts

Natural
Products