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Results for "

Ambler

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111521
    Meropenem-vaborbactam

    Carbavance

    		 Antibiotic Bacterial Beta-lactamase Infection
    Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL .
    Meropenem-vaborbactam
  • HY-132824
    Ledaborbactam etzadroxil

    VNRX-7145

    		 Beta-lactamase Bacterial Infection
    Ledaborbactam etzadroxil (VNRX-7145) is an orally active Ambler class A, C, and D β-lactamase enzymes inhibitor .
    Ledaborbactam etzadroxil
  • HY-145158
    Temocillin

    		Bacterial Antibiotic Drug Derivative Beta-lactamase Infection
    Temocillin is a derivative of Ticarcillin (HY-100577) and a β-lactamase-resistant Antibiotic. Temocillin blocks water molecules from entering the active sites of Ambler class A and class C serine-dependent β-lactamases, resisting hydrolysis by these enzymes. Temocillin exhibits antibacterial activity against Enterobacteriaceae and Neisseria gonorrhoeae. Temocillin shows antagonistic effects against some isolated strains when used in combination with Ticarcillin (HY-100577) or Cefazolin (HY-B1892). Temocillin can be used in research related to sepsis, urinary tract infections, and lower respiratory tract infections .
    Temocillin
  • HY-14879E
    rel-Avibactam sodium

    NXL-104 sodium

    		 Beta-lactamase Bacterial Infection
    Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes .
    rel-Avibactam sodium
  • HY-120235
    CB-618

    		Beta-lactamase Bacterial Infection
    CB-618 is a β-lactamase inhibitor. CB-618 reversibly covalently inhibits Ambler class A, C, and some class D serine β-lactamases. CB-618 has weak antibacterial activity as a single agent, but it significantly enhances the antibacterial activity of Meropenem (HY-13678) against enzyme-producing Enterobacteriaceae. CB-618 can be used in research on drug-resistant bacteria .
    CB-618
  • HY-14879D
    ent-Avibactam sodium

    AVE1330A

    		 Beta-lactamase Bacterial Infection
    Ent-Avibactam sodium (AVE1330A) is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), ent-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of ent-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes .
    ent-Avibactam sodium

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