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Ceftazidime dihydrochloride

(Synonyms: GR20263 dihydrochloride)
46 Cited Publications
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Based on 46 publication(s) in Google Scholar

Ceftazidime (GR20263) dihydrochloride is a cephalosporin β-lactam antibiotic. Ceftazidime dihydrochloride exhibits activity against susceptible Enterobacteriaceae, multidrug-resistant Gram-negative bacteria, Pseudomonas aeruginosa, and bacteria producing Ambler class A, C, and some class D β-lactamases, but shows no activity against microorganisms producing metallo-β-lactamases. Ceftazidime dihydrochloride reduces bacterial loads in mouse models of splenic, hepatic, and thigh infections, but has low efficacy against ESBL- and KPC-producing Enterobacteriaceae. Ceftazidime dihydrochloride can be used in research related to complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired pneumonia, carbapenemase-producing Klebsiella pneumoniae infections, carbapenem-resistant Enterobacterales infections, and severe Gram-negative bacterial infections.

For research use only. We do not sell to patients.

  • CAS No.: 73547-70-3
  • Formula: C22H24Cl2N6O7S2
  • Molecular Weight:619.50
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Ceftazidime dihydrochloride Chemical Structure
    Ceftazidime dihydrochloride Chemical Structure
  • Experimental Validation Results for Ceftazidime dihydrochloride
  • Experimental Validation Results for Ceftazidime dihydrochloride
  • Experimental Validation Results for Ceftazidime dihydrochloride
  • Experimental Validation Results for Ceftazidime dihydrochloride
  • Experimental Validation Results for Ceftazidime dihydrochloride
CAS No.: 73547-70-3
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  • Ceftazidime dihydrochloride Chemical Structure
    Ceftazidime dihydrochloride Chemical Structure
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    Ceftazidime dihydrochloride purchased from MedChemExpress. Usage Cited in: Mol Syst Biol. 2025 Jun 30. [Abstract]

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     Growth and cadaverine production dynamics in E. coli treated with 20 µM of Ceftazidime. Treated cultures show a brief period where the optical density (Absorbance, 595 nm) increases, concurrent with a burst of cadaverine production far above untreated levels. This indicates that this β-lactam antibiotic does not immediately kill the cells but allows for a brief period of growth and stress-induced polyamine production prior to bacterial cell lysis. Lines indicate the mean, and shaded areas the standard deviation of n = 6 biological replicates.

  • 1/16

    Ceftazidime dihydrochloride purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]

    Customer Validation
     Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

  • 1/16

    Ceftazidime dihydrochloride purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]

    Customer Validation
     Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.

  • 1/16

    Ceftazidime dihydrochloride purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2022 Sep 30;77(10):2803-2808. [Abstract]

    Customer Validation
     In vivo change in log10 cfu/thigh of each isolate treated with saline control, Ceftazidime 2 g IV q8h 2 h infusion HSR, Ceftazidime/Avibactam 2.5 g q8h 2 h infusion HSR or meropenem 2 g q8h 3 h infusion HSR for three P. aeruginosa with inserted GES β-lactamases. (a) PSA 2136, with inserted GES-1 (ESBL). (b) PSA 2137, with inserted GES-5 (carbapenemase). (c) PSA 2138, with inserted GES-15. P values in the boxes represent the results from one-way ANOVA; P values are presented if between-group differences were present. The x-axis describes the treatment HSR [MIC (mg/L), % fT>MIC]. CAZ, Ceftazidime; CAZ-AVI, Ceftazidime/Avibactam; MEM, meropenem.

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    Ceftazidime dihydrochloride purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]

    Customer Validation
     The cumulative MIC distributions of Cefepime/Taniborbactam, Ceftazidime/Avibactam and comparator Meropenem for 500 tested isolates. The MICs of cefepime and Cefepime/Taniborbactam shown in the figure were tested by the broth microdilution method. The MICs of Meropenem shown in the figure were tested by the agar dilution method. SS, susceptible to all tested β-lactams. SS-P. aeruginosa, meropenem-susceptible P. aeruginosa. Nine IMP producers included three blaIMP-producing P. aeruginosa.

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