1383814-68-3
Chemical Structure
ent-Avibactam
Synonym(s): ent-NXL-104; ent-AVE1330A
- CAS No.: 1383814-68-3
- Formula:C7H10N3NaO6S
- Molecular Weight:287.23
IUPAC Name: sodium (1S,2R,5S)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
InChIKey: RTCIKUMODPANKX-UYXJWNHNSA-M
SMILES: NC([C@@H]1[N@]2C(N([C@](CC1)([H])C2)OS(=O)(O[Na])=O)=O)=O
Biological Activity: Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes[1][2].
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ent-Avibactam | Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes. | |||||||||||||||||||||
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