1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Ticarcillin

Ticarcillin 

Cat. No.: HY-139805
Handling Instructions

Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research.

For research use only. We do not sell to patients.

Ticarcillin Chemical Structure

Ticarcillin Chemical Structure

CAS No. : 34787-01-4

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Description

Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research[1][2][3].

In Vitro

Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Ps. aeruginosa
Concentration: 10 mg/L
Incubation Time: 18 hours
Result: Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L.
In Vivo

Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect[2].
Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss type male mice injected with Ps. aeruginosa[2]
Dosage: 50, 100, 200 mg/kg
Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once
Result: Increased effect significantly (0.001 < P < 0.0025) with increasing dose.
Animal Model: Swiss type male mice injected with Ps. aeruginosa[2]
Dosage: 50, 100, 200 mg/kg
Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:
Dose (mg/kg) AUCa (mg/kg) Kelb (h-1) T1/2 (min)
Ticarcillin 50 8.76 (0.72) 1.57 (0.18) 26
100 26.14 (0.60) 1.53 (0.11) 27
200 54.56 (2.90) 1.47 (0.12) 28
Molecular Weight

384.43

Formula

C15H16N2O6S2

CAS No.
SMILES

OC([[email protected]](C1=CSC=C1)C(N[[email protected]]2[[email protected]]3([H])N(C2=O)[[email protected]](C(C)(S3)C)C(O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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