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B1269

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By Targets:	Amyloid-β (1) Arf Family GTPase (1) Cannabinoid Receptor (1) E-Selectin (1) L-Selectin (1) MicroRNA (8) P-selectin (3) Reference Standards (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (3) Neurological Disease (2)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106139

Bimosiamose 4 Publications Verification TBC-1269	P-selectin L-Selectin E-Selectin	Inflammation/Immunology
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC₅₀s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .

HY-RI00181A

*hsa-miR-1269a antagomir*	MicroRNA	Cancer
hsa-miR-1269a antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-1269a antagomir hsa-miR-1269a antagomir

HY-177269

CHNQD-01269	Arf Family GTPase	Cancer
CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC₅₀ values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research .

HY-106139A

Bimosiamose disodium TBC-1269Z	P-selectin	Inflammation/Immunology
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC₅₀s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects .

HY-167865

*O-1269*	Cannabinoid Receptor	Neurological Disease
O-1269 is a partial agonist of cannabinoid receptor 1 (CB1R) with a K_i of 32 nM. O-1269 shows analgesic effects .

HY-14535

SEN-1269	Amyloid-β	Neurological Disease
SEN-1269 is a potent Aβ aggregation inhibitor. SEN-1269 blocks Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42). SEN-1269 reduces the deficits in LTP and memory induced by Aβ oligomers. SEN-1269 can be used for the research of Alzheimer's disease .

HY-106139R

Bimosiamose (Standard) TBC-1269 (Standard)	P-selectin Reference Standards	Inflammation/Immunology
Bimosiamose (Standard) is the analytical standard of Bimosiamose. This product is intended for research and analytical applications. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .

HY-R00181

*hsa-miR-1269a mimic*	MicroRNA	Cancer
hsa-miR-1269a mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-1269a mimic hsa-miR-1269a mimic

HY-R00182

*hsa-miR-1269b mimic*	MicroRNA	Cancer
hsa-miR-1269b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-1269b mimic hsa-miR-1269b mimic

HY-R00181A

*hsa-miR-1269a agomir*	MicroRNA	Cancer
hsa-miR-1269a agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-1269a agomir hsa-miR-1269a agomir

HY-RI00182

*hsa-miR-1269b inhibitor*	MicroRNA	Cancer
hsa-miR-1269b inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-1269b inhibitor hsa-miR-1269b inhibitor

HY-RI00182A

*hsa-miR-1269b antagomir*	MicroRNA	Cancer
hsa-miR-1269b antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-1269b antagomir hsa-miR-1269b antagomir

HY-R00182A

*hsa-miR-1269b agomir*	MicroRNA	Cancer
hsa-miR-1269b agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-1269b agomir hsa-miR-1269b agomir

HY-RI00181

*hsa-miR-1269a inhibitor*	MicroRNA	Cancer
hsa-miR-1269a inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-1269a inhibitor hsa-miR-1269a inhibitor

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81524

	VIPR1 Antibody (YA1269) vasoactive inTinal peptide receptor 1; II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2	IHC-P	Human
	VIPR1 Antibody (YA1269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VIPR1.

HY-P81524A

	VIPR1 Antibody (YA1269)(PBS only) vasoactive inTinal peptide receptor 1; II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2	IHC-P	Human
	VIPR1 Antibody (YA1269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VIPR1.

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Cat. No.	Product Name		Classification

HY-RI00181A

*hsa-miR-1269a antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-1269a antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R00181

*hsa-miR-1269a mimic*		MicroRNAs miRNA mimics
hsa-miR-1269a mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R00182

*hsa-miR-1269b mimic*		MicroRNAs miRNA mimics
hsa-miR-1269b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R00181A

*hsa-miR-1269a agomir*		MicroRNAs miRNA agomirs
hsa-miR-1269a agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00182

*hsa-miR-1269b inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-1269b inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI00182A

*hsa-miR-1269b antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-1269b antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R00182A

*hsa-miR-1269b agomir*		MicroRNAs miRNA agomirs
hsa-miR-1269b agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00181

*hsa-miR-1269a inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-1269a inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

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