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Results for "

BACE1-IN-1

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Peptides

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119689
    Umibecestat
    1 Publications Verification

    CNP520

    		 Beta-secretase Neurological Disease
    Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively . Umibecestat can be used for the research of alzheimer's disease.
    Umibecestat
  • HY-100182
    BACE1-IN-1

    		Beta-secretase Neurological Disease
    BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
    BACE1-IN-1
  • HY-W015515
    L-Citronellol

    (S)-3,7-Dimethyloct-6-en-1-ol

    		 Environmental Pollutants TNF Receptor Beta-secretase γ-secretase ERK Cholinesterase (ChE) Neurological Disease Inflammation/Immunology
    L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD) .
    L-Citronellol
  • HY-P4920
    Mca-SEVNLDAEFK(Dnp)-NH2

    		Fluorescent Dye Others
    Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
    Mca-SEVNLDAEFK(Dnp)-NH2
  • HY-W015515R
    L-Citronellol (Standard)

    (S)-3,7-Dimethyloct-6-en-1-ol (Standard)

    		 Reference Standards ERK Beta-secretase γ-secretase Cholinesterase (ChE) TNF Receptor Neurological Disease Inflammation/Immunology
    L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is an analytical standard for L-Citronellol (HY-W015515). This product is intended for research and analytical applications. L-Citronellol is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).
    L-Citronellol (Standard)
  • HY-100182R
    BACE1-IN-1 (Standard)

    		Beta-secretase Reference Standards Neurological Disease
    BACE1-IN-1 (Standard) is the analytical standard of BACE1-IN-1 (HY-100182). This product is intended for research and analytical applications. BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
    BACE1-IN-1 (Standard)
  • HY-147658
    AChE/BChE/BACE-1-IN-1

    		Cholinesterase (ChE) Beta-secretase ROS Kinase Neurological Disease
    AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential .
    AChE/BChE/BACE-1-IN-1
  • HY-178374
    BACE-1/Mpro-IN-1

    		Beta-secretase SARS-CoV Infection Neurological Disease
    BACE-1/Mpro-IN-1 is a high brain-penetrant BACE-1 (IC50 = 0.26 μM) and SARS-CoV-2 Mpro (IC50 = 0.91 μM) dual inhibitor. BACE-1/Mpro-IN-1 binds to the aspartyl protease and cysteine protease as a mixed-type inhibitor. BACE-1/Mpro-IN-1 exhibits the most favorable docking score and a strong interaction profile. BACE-1/Mpro-IN-1 can be used for the study of COVID-19 exacerbated Neuroinflammation and Alzheimer’s disease .
    BACE-1/Mpro-IN-1
  • HY-112297
    BACE-1 inhibitor 1

    		Beta-secretase Neurological Disease
    BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC50 of 56 nM .
    BACE-1 inhibitor 1
  • HY-P3426
    BACE1-IN-10

    		Beta-secretase Cancer
    BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1) .
    BACE1-IN-10
  • HY-183375
    AChE/BuChE/BACE-1-IN-1

    		Neurological Disease
    AChE/BuChE/BACE-1-IN-1 is a blood-brain barrier-permeable multi-target inhibitor of AChE/BuChE/BACE, with IC50 values of 0.387 μM, 0.430 μM, and 0.531 μM against AChE, BuChE, and BACE-1, respectively. AChE/BuChE/BACE-1-IN-1 reduces the aggregation of β-amyloid protein (Aβ) and hyperphosphorylated tau protein (p-tau). AChE/BuChE/BACE-1-IN-1 can be used for the research of Alzheimer's disease .
    AChE/BuChE/BACE-1-IN-1

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