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Results for "

CCND1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Natural
Products

5

Recombinant Proteins

8

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0692
    Schisandrol B
    2 Publications Verification

    Gomisin-A; TJN-101; Wuweizi alcohol-B

    		 Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy Cancer
    Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities [1] .
    Schisandrol B
  • HY-168660
    CPD-10
    1 Publications Verification

    		 PROTACs Apoptosis CDK Cancer
    CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 exhibits anti-proliferative effects on tumor cells and can also induce apoptosis. CPD-10 can be used for the study of breast cancer and lung cancer [1].
    CPD-10
  • HY-168664
    CPD-39

    		PROTACs CDK Cancer
    CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667)) [1].
    CPD-39
  • HY-119271
    CMLD010509

    SDS-1-021

    		 c-Myc Apoptosis Cancer
    CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism [1].
    CMLD010509
  • HY-RS02123
    CCND1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CCND1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCND1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CCND1 Human Pre-designed siRNA Set A
    CCND1 Human Pre-designed siRNA Set A
  • HY-RS16780
    Ccnd1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ccnd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccnd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ccnd1 Mouse Pre-designed siRNA Set A
    Ccnd1 Mouse Pre-designed siRNA Set A
  • HY-RS23220
    Ccnd1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ccnd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccnd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ccnd1 Rat Pre-designed siRNA Set A
    Ccnd1 Rat Pre-designed siRNA Set A
  • HY-119271A
    (-)-CMLD010509

    (-)-SDS-1-021

    		 c-Myc Apoptosis Cancer
    (-)-CMLD010509 ((-)-SDS-1-021) is an isomer of CMLD010509 (SDS-1-021) (HY-119271). CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism [1].
    (-)-CMLD010509
  • HY-181131
    Anticancer agent 300

    		CDK Cancer
    Anticancer agent 300 (compound P14) is a CCND1, CDK4, CDK6, and CCNE1 modulator, with anti-proliferative, cell-cycle modulatory, senescence-inducing, and apoptosis-inducing activity. Anticancer agent 300 can be used for the research of ER+/HER2− breast cancer and BRAF-mutant melanoma [1].
    Anticancer agent 300
  • HY-183004
    NCP26

    		Aminoacyl-tRNA Synthetase Apoptosis Caspase PARP c-Myc Cancer
    NCP26 is an ATP-competitive ProRS inhibitor (with a KD of 271 nM in the absence of proline, and a KD of 0.35 nM in the presence of 100 μM proline). NCP26 activates AAR, induces G0/G1 phase arrest, Apoptosis, Caspase cleavage, and PARP cleavage. NCP26 downregulates MYC, TCF3, and CCND1. NCP26 inhibits the growth of multiple myeloma cells. NCP26 can be used for the research of multiple myeloma [1] .
    NCP26
  • HY-N0692R
    Schisandrol B (Standard)

    Gomisin-A (Standard); TJN-101 (Standard); Wuweizi alcohol-B (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy Cancer
    Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities [1] .
    Schisandrol B (Standard)
  • HY-181769
    Anticancer agent 306

    		MMP Polo-like Kinase (PLK) CDK PAK Bcl-2 Family Caspase Apoptosis Cancer
    Anticancer agent 306 is a spiro tetramic acid derivative and a inhibitor of MMP1, MMP7 and PLK1. Anticancer agent 306 exerts antiproliferative activity against H1299, RKO and MCF-7 cells with IC50 values of 19.25 μM, 3.29 μM and 102.36 μM, respectively. Anticancer agent 306 can up-regulate p21 protein and down-regulate CCND1 and CCNB1 proteins to induce cell cycle arrest, regulate the expression of Bcl-2 and Bax to induce cell apoptosis. Anticancer agent 306 can down-regulate MMP1 and MMP7 proteins to inhibit tumor invasion and metastasis. Anticancer agent 306 can be used for the research of lung cancer, colorectal cancer, breast cancer [1].
    Anticancer agent 306

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