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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
CDC-like
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "CDC-like" in MCE Product Catalog:
4
4 Cited Publications
CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity .
2
Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors research .
1
1 Cited Publications
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) and CDC-like kinases (CLKs). Leucettine L41 can also inhibit GSK-3 singnaling. Leucettine L41 can inhibit cell apoptosis and ROS production. Leucettine L41 can promote β-cell cell cycle progression, cell proliferation and increase insulin secretion. Leucettine L41 can be used for the researches of neurological disease and metabolic disease, such as Alzheimer’s disease (AD) and diabetes .
1
1 Cited Publications
Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50 of 1 nM and 7 nM for CLK2 (human) and CLK3 (human), respectively. Ipivivint also inhibits the Wnt pathway (EC50=13 nM) and tyrosine phosphorylation-regulated kinase 1A (human) (EC50=5 nM) .
MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed) .
製品番号: HY-179177
CAS 番号: 1081122-55-5
Target:
研究分野:
AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor (IC50 = 0.29 μM) and shows a significant inhibitory effect on (CDC-like kinase 1) CLK1 (IC50 = 0.08 μM). AO-365/43472821 could protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid (HY-N6785) (OA)-induced injury. AO-365/43472821 decreased tau (pSer396)/tau and Aβ1-42 protein expression. AO-365/43472821 can be used for the study of Alzheimer's disease .
製品番号: HY-400528
CAS 番号: 332939-32-9
Target:
CLK1-IN-4 (Compound 81) is an inhibitor for CDC like kinase 1 (CLK-1) with IC50 of 2.5 μM .
製品番号: HY-130676
CAS 番号: 2561494-73-1
CLK-IN-T3N, the negative control of CLK-IN-T3 (HY-115470), is a chemical probe for CDC-like kinase (CLK).
製品番号: HY-P701664
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: CLK2; Dual specificity protein kinase CLK2; CDC-like kinase 2
製品番号: HY-P705761
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: Dual specificity protein kinase CLK1; CDC-like kinase 1
Species:
Source:
製品番号: HY-P705763
純度: ≥ 80%, as determined by reducing SDS-PAGE.
別名: Dual specificity protein kinase CLK4; CDC-like kinase 4
Species:
Source:
製品番号: HY-P705762
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: CLK2; Dual specificity protein kinase CLK2; CDC-like kinase 2
Species:
Source:
製品番号: HY-P705578
別名: Dual specificity protein kinase CLK3; CDC-like kinase 3; EC:2.7.12.1
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
