Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
CHI
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "CHI" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-P70030
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CHI3L1; HCGP-39; CHItinase 3 Like 1; CGP-39; CHItinase-3-Like Protein 1; YKL-40; YKL40; GP-39; YK-40; CHI3L1 Protein; GP39; HC-Gp39; CHItinase 3-Like 1 (Cartilage Glycoprotein-39); HCGP-3P; Cartilage Glycoprotein-39; YYL-40; Cartilage Glycoprotein 39; ASR
3
3 Cited Publications
Cat. No.: HY-P7845
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ym1; CHI3l3; CHIl3; Secreted protein Ym1; Eosinophil chemotactic cytokine; ECF-L; CHItinase-3-like protein 3; Beta-N-acetylhexosaminidase Ym1; EC:3.2.1.52; CHItinase-like protein 3; rMuCHItinase-like protein 3/YM1, His
2
2 Cited Publications
Research Areas:
K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury .
2
2 Cited Publications
Research Areas:
BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research .
1
1 Cited Publications
Cat. No.: HY-P76702
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CHI3L1; HCGP-39; CHItinase 3 Like 1; CGP-39; CHItinase-3-Like Protein 1; YKL-40; YKL40; GP-39; YK-40; CHI3L1 Protein; GP39; HC-Gp39; CHItinase 3-Like 1 (Cartilage Glycoprotein-39); HCGP-3P; Cartilage Glycoprotein-39; YYL-40; Cartilage Glycoprotein 39; ASR
Cat. No.: HY-163387
CAS No.: 2982256-78-8
Target:
Research Areas:
CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC50 of 50 nM. CHI3L1-IN-1 inhibits hERG channel with an IC50 of 2.3 μM .
Synonyms: CHI 621
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Cat. No.: HY-175207
CAS No.: 3109469-27-1
Target:
Research Areas:
CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM .
Cat. No.: HY-P99321
CAS No.: 299423-37-3
Synonyms: BMS 224819; CHI220; Anti-Human CD40 Recombinant Antibody
Target:
Research Areas:
Cat. No.: HY-163388
CAS No.: 2982257-63-4
Target:
Research Areas:
CHI3L1-IN-2 (Compound 36) is a CHI3L1 (Chitinase-3-Like Protein 1) inhibitor. CHI3L1-IN-2 inhibits the? interaction between CHI3L1 and heparan sulfate (CHI3L1:HSIII), with an IC50 of 26 nM. CHI3L1, also known as YKL-40, is a glycoprotein associated with inflammation, fibrosis, and cancer .
Cat. No.: HY-171656
CAS No.: 946378-12-7
Target:
Glycosidase NF-κB COX STAT ERK p38 MAPK Apoptosis CDK Survivin Bcl-2 Family
Research Areas:
G721-0282 is an orally active CHI3L1 inhibitor. G721-0282 can reduce the expression of inflammatory proteins and cytokines. G721-0282 inhibits the activation of the NF-κB signaling pathway. G721-0282 inhibits neuroinflammation and reduces anxious behavior. G721-0282 significantly inhibits the proliferation of osteosarcoma (OS) cells by suppressing the STAT3 signaling pathway. G721-0282 induces OS cell apoptosis by upregulating pro-apoptotic protein levels and downregulating anti-apoptotic protein levels. G721-0282 can be used for researches on neuroinflammatory conditions and cancer .
Cat. No.: HY-P990366
Target:
Research Areas:
Cat. No.: HY-169249
Synonyms: Z1620764636
Target:
Research Areas:
Aekatperone is a reversible KATP channel inhibitor, with an IC50 of 9 μM. Aekatperone can be used for the research of congenital hyperinsulinism (CHI) .
Cat. No.: HY-168428
Target:
Research Areas:
CHI-KAT8i5 is a selective and orally active KAT8 inhibitor with a KD value of 19.72 μM. CHI-KAT8i5 does not bind to other proteins in HAT family (KAT2A, KAT2B, KAT5, and KAT7). CHI-KAT8i5 induces cancer cell apoptosis. CHI-KAT8i5 suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway .
Cat. No.: HY-RS02627
Target:
Research Areas:
CHI3L2 Human Pre-designed siRNA Set A contains three designed siRNAs for CHI3L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175781
CAS No.: 1258696-85-3
Target:
Research Areas:
CHI3L1-IN-4 (Compound 8) is a Chitinase-3-Like Protein 1 (CHI3L1) inhibitor with a Kd of 6.8 μM. CHI3L1-IN-4 significantly reduces glioblastoma (GBM) spheroids viability and attenuates phospho-STAT3 levels by disrupting CHI3L1 pathway. CHI3L1-IN-4 can be used for GBM research .
Cat. No.: HY-179214
Target:
Research Areas:
DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease .
Cat. No.: HY-RS02626
Target:
Research Areas:
CHI3L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHI3L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-156363
CAS No.: 905794-70-9
K-Ras-IN-2 (Compound CHI-000-667) is a K-Ras antagonist, and can be used for tumor research .
Cat. No.: HY-149864
Target:
Research Areas:
Insecticidal agent 3 is a multichitinase inhibitors, belongs to insect growth regulators (IGRs)，with Kis of 0.8μM, 11.9 μM, and 2.3 μM for Of ChtI, Of ChtII, and Of Chi-h, respectively. Insecticidal agent 3 exhibits insecticidal activity against two lepidopteran pests by interfering with normal insect growth and molting .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
