Basiliximab
Based on 1 Customer Validation
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.692%
- CAS 番号: 179045-86-4
- 分子量:143.56 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-P99486
BriakinumabAnti-IL-12/23p40 Antibody -
HY-P9924
IxekizumabIL-17A Antagonist -
HY-P9907
TrastuzumabHER2 Blocking Antibody -
HY-P9917
TocilizumabIL-6R Neutralizing Antibody -
HY-P99111
GolimumabTNFα Antagonist -
HY-P9909
Ustekinumab -
HY-P99248
RisankizumabIL-23 IgG Monoclonal Antibody -
HY-P9910
Obinutuzumab (FUT8-KO)Anti-CD20 Antibody -
HY-P9931
GuselkumabIL-23 Neutralizing Antibody -
HY-108738
DaclizumabCD25 Blocker -
HY-P9927
SecukinumabIL-17A Antagonist -
HY-108810
CanakinumabAnti-IL-1β Monoclonal Antibody
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IL-2Ra/CD25
体外実験
Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα[1].
Basiliximab binds only to activated lymphocytes and macrophages/monocytes[3].
Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Timed-pregnant Sprague Dawley (SD) rats, reduced uterine perfusion pressure (RUPP) rat model of placental ischemia[2]
-
Dosage:0.07 mg/rat
-
Administration:IV infusion, once
-
Result:Decreased total placental natural killer cells. Had no effect to lower MAP or improve pup weight and placental weight.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized IL-2R alpha/CD25 Protein, Human (HEK293, C-His, HY-P70628) can bind Basiliximab. The EC50 for this effect is 35.99 ng/mL. -
化学情報
-
CAS 番号 179045-86-4
-
性状 Liquid
-
分子量 143.56 kDa
-
Color Colorless to light yellow
-
SMILES
[Basiliximab]
-
別名
CHI 621
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
-
データシート (260 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. McKeage K, et al. Basiliximab: a review of its use as induction therapy in renal transplantation. BioDrugs. 2010 Feb 1;24(1):55-76. [Content Brief]
[3]. Chapman TM, et al. Basiliximab: a review of its use as induction therapy in renal transplantation. Drugs. 2003;63(24):2803-35. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Basiliximab 関連分類
HY-108852 関連分類
Powered by Bioz