DEL-C1 

DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease^[1].

DEL-C1 (5-25 μM, 30 mins) restores the CHI3L1-induced decrease in Aβ_1-42 uptake in human iPSC-derived astrocytes^[1].
DEL-C1 (5-25 μM, 30 mins) improves the CHI3L1-inhibited lysosomal degradation of DQ-BSA in the astrocytes^[1].
DEL-C1 (5-25 μM, 30 mins) inhibits CHI3L1-driven secretion of CHI3L1 and IL-6 and activation of NF-κB in the astrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

695.87

C₃₈H₄₅N₇O₄S

CNC(C[C@H](C1=CC=CC=C1)NC(C[C@@H](NC([C@@H]2CCCC[C@H]2NCC3=CN=C(O3)C4=C(N=C(S4)C)C)=O)CC5=CNC6=C5C=CC=C6)=O)=O

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• [1]. Kaur B, et al. Discovery of a CHI3L1-Targeted Small Molecule Modulating Neuroinflammation in Alzheimer's Disease via DNA-Encoded Library (DEL) Screening †. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683491.  [Content Brief]