702668-62-0
Chemical Structure
K284-6111
- CAS No.: 702668-62-0
- Formula:C30H37N3O4S
- Molecular Weight:535.70
IUPAC Name: 2-((3-(2-(cyclohex-1-en-1-yl)ethyl)-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(4-ethylphenyl)butanamide
InChIKey: FMKHSHNIKAKCRV-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=C(N1CCC3=CCCCC3)SC(CC)C(NC4=CC=C(CC)C=C4)=O)C=C(OC)C(OC)=C2
Biological Activity: K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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K284-6111 | 99.94% | K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury. | ||||||||||||||||||||
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- [1]. Ham HJ, et al. K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway. J Neuroinflammation. 2020 Nov 22;17(1):350. [Content Brief]
- [2]. Choi JY, et al. K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression. J Neuroinflammation. 2018 Aug 11;15(1):224. [Content Brief]
- [3]. Jeon SH, et al. Inhibition of Chitinase-3-like-1 by K284-6111 Reduces Atopic Skin Inflammation via Repressing Lactoferrin. Immune Netw. 2021 Jun 29;21(3):e22. [Content Brief]
- [4]. Inhibition of Chitinase-3-like-1 expression by K284 ameliorates lipopolysaccharide-induced acute liver injury through down regulation of CXCL3.
Keywords
