CXCL13

By Targets:	Apoptosis (1) ATP Citrate Lyase (1) Btk (1) CXCR (6) PI3K (1) Small Interfering RNA (siRNA) (3) TNF Receptor (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-175606

EVT0185	ATP Citrate Lyase	Cancer
EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC₅₀ of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .

HY-P991567

VX5 VX5/5261	CXCR	Inflammation/Immunology Cancer
VX5 (VX5/5261) is a humanized IgG1κ monoclonal antibody inhibitor targeting *BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated* internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration. VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer .

HY-P99459

Baminercept 2 Publications Verification BG 9924; TT-47	TNF Receptor CXCR	Inflammation/Immunology
Baminercept (BG 9924; TT-47) is an Ig fusion protein targeting the lymphotoxin β receptor (LTβR). Baminercept effectively regulates subsets of circulating immune cells by inhibiting LIGHT, LT-α1β2 and their receptors. Baminercept also increases blood lymphocyte counts and reduces plasma *CXCL13* levels. Baminercept carries a high risk of hepatotoxicity. Baminercept can be used in research on rheumatoid arthritis and primary Sjögren's syndrome .

HY-RS23036

Cxcl13 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cxcl13 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcl13 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcl13 Rat Pre-designed siRNA Set A Cxcl13 Rat Pre-designed siRNA Set A

HY-RS03387

CXCL13 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CXCL13 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCL13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CXCL13 Human Pre-designed siRNA Set A CXCL13 Human Pre-designed siRNA Set A

HY-163480

PF-06835375	CXCR	Inflammation/Immunology
PF-06835375 is a selective, humanized CXCR5-targeting immunoglobulin G1 antibody. PF-06835375 depletes CXCR5-positive B cells, follicular helper T cells and circulating Tfh-like cells. PF-06835375 is applicable to research related to autoimmune diseases .

HY-RS16602

Cxcl13 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cxcl13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcl13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcl13 Mouse Pre-designed siRNA Set A Cxcl13 Mouse Pre-designed siRNA Set A

HY-P992222

*Anti-CXCL13* Antibody**	CXCR	Inflammation/Immunology
Anti-CXCL13 Antibody is a monoclonal antibody targeting CXCL13. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CXCL13 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992476

TJX7	CXCR	Cancer
TJX7 is a recombinant antibody targeting *CXCL13/BCA-1/BLC*.

HY-182774

YU241279	CXCR	Cancer
YU241279 is an orally active CXCR5 inhibitor. YU241279 inhibits *CXCL13*-mediated Gαq-dependent calcium influx and Gαi2-dependent cAMP reduction in CXCR5-expressing cells. YU241279 inhibits the proliferation of CXCR5-expressing lymphoma cells. YU241279 reduces tumor burden in the peripheral blood and bone marrow of mice implanted with lymphoma tissues. YU241279 is well tolerated during oral administration in mice, maintains stable plasma drug concentrations, and shows no metabolic changes. YU241279 can be used in the research of angioimmunoblastic T-cell lymphoma and Burkitt B-cell lymphoma .

HY-182671

SRX3305	PI3K Btk Apoptosis	Cancer
SRX3305 is an BTK/PI3K/BRD4 inhibitor with IC₅₀s of 6.5 nM, 15 nM, and 4 nM toward BTK, PI3Kɑ and PI3Kδ, respectively. SRX3305 attenuates chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) cell proliferation and promotes apoptosis in a dose-dependent fashion. SRX3305 yields potent anti-tumor effects but spares healthy bystander cells. SRX3305 inhibits the activation-induced proliferation of primary CLL cells in vitro and effectively blocks microenvironment-mediated survival signals. SRX3305 blocks CLL cell migration toward *CXCL-12* and *CXCL-13*. SRX3305 maintains its anti-tumor effects in Ibrutinib (HY-10997)-resistant CLL cells. SRX3305 can be used for research in CLL, diffuse large B-cell lymphoma (DLBCL) and MCL .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991567

VX5 VX5/5261	CXCR	Inflammation/Immunology Cancer
VX5 (VX5/5261) is a humanized IgG1κ monoclonal antibody inhibitor targeting *BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated* internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration. VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer .

HY-P99459

Baminercept 2 Publications Verification BG 9924; TT-47	TNF Receptor CXCR	Inflammation/Immunology
Baminercept (BG 9924; TT-47) is an Ig fusion protein targeting the lymphotoxin β receptor (LTβR). Baminercept effectively regulates subsets of circulating immune cells by inhibiting LIGHT, LT-α1β2 and their receptors. Baminercept also increases blood lymphocyte counts and reduces plasma *CXCL13* levels. Baminercept carries a high risk of hepatotoxicity. Baminercept can be used in research on rheumatoid arthritis and primary Sjögren's syndrome .

HY-163480

PF-06835375	CXCR	Inflammation/Immunology
PF-06835375 is a selective, humanized CXCR5-targeting immunoglobulin G1 antibody. PF-06835375 depletes CXCR5-positive B cells, follicular helper T cells and circulating Tfh-like cells. PF-06835375 is applicable to research related to autoimmune diseases .

HY-P992222

*Anti-CXCL13* Antibody**	CXCR	Inflammation/Immunology
Anti-CXCL13 Antibody is a monoclonal antibody targeting CXCL13. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CXCL13 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992476

TJX7	CXCR	Cancer
TJX7 is a recombinant antibody targeting *CXCL13/BCA-1/BLC*.

Species:	Human (3) Mouse (2) Rat (1) Cynomolgus (1) Pig (1)
Tag:	His (6) Tag Free (1) GST (1) Fc (1)
Source:	HEK293 (2) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700234AF

	*Animal-Free CXCL13* Protein, Pig (His)** C-X-C motif chemokine 13; BCA1; BLC; SCYB13	Pig	E. coli
	The CXCL13 protein is a member of the intercrine α family and is critical for chemokines involved in intercellular communication and immune responses. In this family, CXCL13 may play a key role in regulating inflammatory processes and influencing cellular interactions. Animal-Free CXCL13 Protein, Pig (His) is the recombinant pig-derived animal-FreeCXCL13 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P7131

	*BCA-1/CXCL13* Protein, Human** 3 Publications Verification rHuBCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13	Human	E. coli
	CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Human is produced in E. coli, and consists of 87 amino acids (V23-P109).

HY-P700044AF

	*Animal-Free BCA-1/CXCL13* Protein, Human (His)** BCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13	Human	E. coli
	The BCA-1/CXCL13 protein selectively attracts B lymphocytes without affecting T lymphocytes, monocytes, or neutrophils. Unlike other chemokines, it does not induce calcium release from B lymphocytes. Animal-Free BCA-1/CXCL13 Protein, Human (His) is the recombinant human-derived animal-FreeBCA-1/CXCL13 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P76164

	*BCA-1/CXCL13* Protein, Cynomolgus (His)** C-X-C motif chemokine 13; BCA1; BLC; SCYB13	Cynomolgus	E. coli
	CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Cynomolgus (His) is produced in E. coli with a N-Terminal His-tag.

HY-P704362

	*BCA-1/CXCL13* Protein, Human (His)** BCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13	Human	E. coli
	The BCA-1/CXCL13 protein selectively attracts B lymphocytes without affecting T lymphocytes, monocytes, or neutrophils. Unlike other chemokines, it does not induce calcium release from B lymphocytes. BCA-1/CXCL13 Protein, Human (His) is the recombinant human-derived BCA-1/CXCL13 protein, expressed by E. coli, with N-His labeled tag.

HY-P700547

	*BCA-1/CXCL13* Protein, Rat (His-GST)** rHuBCA-1/CXCL13; C-X-C motif chemokine 13; BCA1; BLC; SCYB13	Rat	E. coli
	The BCA-1/CXCL13 protein is a member of the intercrine α family and is critical for chemokines involved in intercellular communication and immune responses. As part of this family, BCA-1/CXCL13 may play a key role in regulating inflammatory processes and influencing cellular interactions. BCA-1/CXCL13 Protein, Rat (His-GST) is the recombinant rat-derived BCA-1/CXCL13 protein, expressed by E. coli , with N-GST, N-6*His labeled tag.

HY-P77911

	*BCA-1/CXCL13* Protein, Mouse (HEK293, His)** 1 Publications Verification ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13	Mouse	HEK293
	CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Mouse (HEK293, His) is produced in HEK293 cells with a N-Terminal His-tag. It consists of 88 amino acids (I22-A109).

HY-P77912

	*BCA-1/CXCL13* Protein, Mouse (HEK293, Fc)** 1 Publications Verification ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13	Mouse	HEK293
	CXCL13, known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant), is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor. CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. BCA-1/CXCL13 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 88 amino acids (I22-A109).

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HY-P87311

	CXCL13 Antibody (YA6994) ANGIE antibody; ANGIE2 antibody; B cell attracting chemokine 1 antibody; B cell-attracting chemokine 1 antibody; B lymphocyte chemoattractant antibody; B-cell chemoattractant antibody; B-cell-attracting chemokine 1 antibody; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1) antibody; BCA-1 antibody; BCA1 antibody	WB, ICC/IF, IHC-P	Human
	CXCL13 Antibody (YA6994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CXCL13.

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Cat. No.	Product Name		Classification

HY-RS23036

Cxcl13 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cxcl13 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcl13 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03387

CXCL13 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CXCL13 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCL13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16602

Cxcl13 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cxcl13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcl13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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