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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Circadian clock
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Circadian clock" in MCE Product Catalog:
3
3 Cited Publications
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Research Areas:
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity .
2
2 Cited Publications
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(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .
2
2 Cited Publications
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KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues .
2
2 Cited Publications
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KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .
1
1 Cited Publications
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CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms .
Cat. No.: HY-W011425
CAS No.: 6419-19-8
Synonyms: Nitrilotris(methylenephosphonic acid)
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NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) .
Cat. No.: HY-134193
CAS No.: 396721-89-4
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KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals .
Cat. No.: HY-W011425A
CAS No.: 7611-50-9
Synonyms: Nitrilotris(methylenephosphonic acid), trisodium salt
Cat. No.: HY-184895
Target:
Cryptochrome REV-ERB Nuclear Hormone Receptor 4A/NR4A FABP PARP Fatty Acid Synthase (FASN) Wnt β-catenin Hormone-Sensitive Lipase (HSL) PGC-1α ROR GLUT
Research Areas:
CM002 is a circadian clock activator. CM002 inhibits the lineage commitment and terminal differentiation of preadipocytes by activating the circadian clock, thereby blocking the adipogenesis process driven by Wnt signaling-mediated transcriptional induction. CM002 attenuates lipid storage in a clock-dependent manner via inhibition of the lipogenic program in mature adipocytes. CM002 enhances circadian clock output across various adipose depots in both lean and obese mice through BMAL1/CLOCK-dependent metabolic reprogramming, inhibits adipocyte development and hypertrophy, and improves insulin sensitivity. CM002 can be used in research on obesity and type 2 diabetes .
Cat. No.: HY-P7S0151
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRY1; Cryptochrome 1 (Photolyase-Like); Prev. PHLL1; DSPD; Cryptochrome-1; Cryptochrome Circadian Regulator 1; Cryptochrome Circadian clock 1
Cat. No.: HY-P87329
Synonyms: 2810049O06Rik antibody; Cell growth inhibiting gene 13 protein antibody; Cell growth-inhibiting gene 13 protein antibody; Circadian clock protein PERIOD 3 antibody; GIG13 antibody; gPER3 antibody; Growth inhibiting protein 13 antibody; HGNC:8847 antibody; hPER3 antibody; mPer3 antibody
Cat. No.: HY-P87329A
Synonyms: 2810049O06Rik antibody; Cell growth inhibiting gene 13 protein antibody; Cell growth-inhibiting gene 13 protein antibody; Circadian clock protein PERIOD 3 antibody; GIG13 antibody; gPER3 antibody; Growth inhibiting protein 13 antibody; HGNC:8847 antibody; hPER3 antibody; mPer3 antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
