6419-19-8
6419-19-8
Chemical Structure
NTPO
Synonym(s): Nitrilotris(methylenephosphonic acid)
- CAS No.: 6419-19-8
- Formula:C3H12NO9P3
- Molecular Weight:299.05
IUPAC Name: (nitrilotris(methylene))tris(phosphonic acid)
InChIKey: YDONNITUKPKTIG-UHFFFAOYSA-N
SMILES: OP(CN(CP(O)(O)=O)CP(O)(O)=O)(O)=O
Biological Activity: NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER)[1].
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NTPO | NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER). | |||||||||||||||||||||
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