25 Results for "

Connexins

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "Connexins" in MCE Product Catalog:

8
Gap 26
Gap 26
0 Images
8 Publications Verification
Cat. No.: HY-P1082
CAS No.: 197250-15-0
Target:  

Connexin Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .
8
Gap 26 TFA
Gap 26 TFA
0 Images
8 Publications Verification
Cat. No.: HY-P1082A
Target:  

Connexin Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .
7
Gap 27
Gap 27
0 Images
7 Cited Publications
Cat. No.: HY-P0139
CAS No.: 198284-64-9
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .
7
Trovafloxacin mesylate
Trovafloxacin mesylate
0 Images
7 Cited Publications
Cat. No.: HY-103399
CAS No.: 147059-75-4
Purity:  99.76%
Target:  

Bacterial Topoisomerase Antibiotic

Research Areas:  

Infection

Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
7
Trovafloxacin
Trovafloxacin
0 Images
7 Cited Publications
Cat. No.: HY-A0170
CAS No.: 147059-72-1
Target:  

Bacterial Topoisomerase Antibiotic

Research Areas:  

Infection

Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
5
Gap19
Gap19
0 Images
5 Cited Publications
Cat. No.: HY-P1136
CAS No.: 1507930-57-5
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .
5
Gap19 TFA
Gap19 TFA
0 Images
5 Cited Publications
Cat. No.: HY-P1136A
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .
2
TAT-Gap19
TAT-Gap19
0 Images
2 Cited Publications
Cat. No.: HY-P1136B
CAS No.: 1507930-54-2
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .
2
TAT-Gap19 TFA
TAT-Gap19 TFA
0 Images
2 Cited Publications
Cat. No.: HY-P1136C
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .
1
Rotigaptide
Rotigaptide
0 Images
1 Cited Publications
Cat. No.: HY-106225
CAS No.: 355151-12-1
Purity:  99.50%
Synonyms: ZP123
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .
TAPS
TAPS
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Cat. No.: HY-D0877
CAS No.: 29915-38-6
TAPS is an aminosulfonate-based lysozyme stabilizer and connexin channel inhibitor. TAPS maintains the native structure of lysozyme in aqueous solution at pH 7.0 and significantly protects it from heat-induced denaturation. TAPS directly inhibits the activity of heteromeric connexin 32/connexin 26 channels (Cx32/Cx26) via its protonated form, and this inhibitory effect is dependent on the presence of connexin 26. TAPS reduces connexin channel-mediated solute exchange in a recombinant liposome system, resulting in a decreased degree of liposome density shift in transport-specific separation assays. TAPS is a critical compound for investigating the structure and function of connexin channels .
Zymosan (ZM), 95%
Zymosan (ZM), 95%
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Cat. No.: HY-159069
CAS No.: 9010-72-4
Purity:  95.02%
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .
Peptide5
Peptide5
0 Images
Cat. No.: HY-P2275
CAS No.: 916977-43-0
Target:  

Gap Junction Protein

Research Areas:  

Neurological Disease

Peptide5, a connexin 43 mimetic peptide, reduce animals swelling, astrogliosis, and neuronal cell death after spinal cord injury
VRT-534
VRT-534
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Cat. No.: HY-149318
CAS No.: 926664-32-6
Target:  

Gap Junction Protein Connexin

Research Areas:  

Others

VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment .
Peptide5 TFA
Peptide5 TFA
0 Images
Cat. No.: HY-P2275B
Target:  

Gap Junction Protein NOD-like Receptor (NLR)

Research Areas:  

Inflammation/Immunology

Peptide5 TFA, a connexin 43 mimetic peptide, reduces animals swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 TFA also inhibits NLRP3 inflammasome, and is an anti-inflammatory agent .
(R,R)-VRT-534
(R,R)-VRT-534
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Cat. No.: HY-149318B
CAS No.: 926664-33-7
Target:  

Connexin Gap Junction Protein

Research Areas:  

Others

(R,R)-VRT-534 is the (R,R)-enantiomer of VRT-534 (HY-149318). VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment .
Connexin mimetic peptide 40GAP27
Connexin mimetic peptide 40GAP27
0 Images
Cat. No.: HY-P5389
CAS No.: 403858-30-0
Target:  

Gap Junction Protein

Research Areas:  

Others

Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)
TAPS sodium
TAPS sodium
0 Images
Cat. No.: HY-W040263
CAS No.: 91000-53-2
Synonyms: TAPS Na
TAPS sodium is a biological buffer that protects the structural integrity of lysozyme bacteria and prevents them from thermal denaturation at high temperatures. A pKa of 8.1 for TAPS results in half-maximal connexin channel activity .
Rotigaptide (Standard)
Rotigaptide (Standard)
0 Images
Cat. No.: HY-106225R
CAS No.: 355151-12-1
Synonyms: ZP123 (Standard)
Target:  

Reference Standards Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .
Lufepirsen
Lufepirsen
0 Images
Cat. No.: HY-177644
CAS No.: 287122-58-1
Target:  

Connexin

Research Areas:  

Others

Lufepirsen is an unmodified antisense oligonucleotide targeted to Connexin43 (Cx43). Connexin43 is a specific protein in the eye, which plays a role in wound healing.
Assay Types