926664-33-7
Chemical Structure
(R,R)-VRT-534
- CAS No.: 926664-33-7
- Formula:C25H24ClN3O4S
- Molecular Weight:497.99
IUPAC Name: 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((R)-(2-chlorophenyl)((R)-3-hydroxypyrrolidin-1-yl)methyl)thiazol-2-yl)cyclopropane-1-carboxamide
InChIKey: OUGLISSDQZYBGK-OPAMFIHVSA-N
SMILES: O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl
Biological Activity: (R,R)-VRT-534 is the (R,R)-enantiomer of VRT-534 (HY-149318). VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].
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(R,R)-VRT-534 | 96.46% | (R,R)-VRT-534 is the (R,R)-enantiomer of VRT-534 (HY-149318). VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment. | ||||||||||||||||||||
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Keywords
