(R,R)-VRT-534
(R,R)-VRT-534 is the (R,R)-enantiomer of VRT-534 (HY-149318). VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26). Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment.
For research use only. We do not sell to patients.
- Purity : 96.46%
- CAS No.: 926664-33-7
- Formula: C25H24ClN3O4S
- Molecular Weight:497.99
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 926664-33-7
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Appearance Solid
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Molecular Weight 497.99
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Formula C25H24ClN3O4S
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Color White to off-white
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SMILES
O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (200.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0081 mL | 10.0404 mL | 20.0807 mL | 50.2018 mL |
| 5 mM | 0.4016 mL | 2.0081 mL | 4.0161 mL | 10.0404 mL | |
| 10 mM | 0.2008 mL | 1.0040 mL | 2.0081 mL | 5.0202 mL | |
| 15 mM | 0.1339 mL | 0.6694 mL | 1.3387 mL | 3.3468 mL | |
| 20 mM | 0.1004 mL | 0.5020 mL | 1.0040 mL | 2.5101 mL | |
| 25 mM | 0.0803 mL | 0.4016 mL | 0.8032 mL | 2.0081 mL | |
| 30 mM | 0.0669 mL | 0.3347 mL | 0.6694 mL | 1.6734 mL | |
| 40 mM | 0.0502 mL | 0.2510 mL | 0.5020 mL | 1.2550 mL | |
| 50 mM | 0.0402 mL | 0.2008 mL | 0.4016 mL | 1.0040 mL | |
| 60 mM | 0.0335 mL | 0.1673 mL | 0.3347 mL | 0.8367 mL | |
| 80 mM | 0.0251 mL | 0.1255 mL | 0.2510 mL | 0.6275 mL | |
| 100 mM | 0.0201 mL | 0.1004 mL | 0.2008 mL | 0.5020 mL |
(R,R)-VRT-534 Related Classifications
HY-149318B Related Classifications
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