29915-38-6
Chemical Structure
TAPS
- CAS No.: 29915-38-6
- Formula:C7H17NO6S
- Molecular Weight:243.28
IUPAC Name: 3-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)propane-1-sulfonic acid
InChIKey: YNLCVAQJIKOXER-UHFFFAOYSA-N
SMILES: O=S(CCCNC(CO)(CO)CO)(O)=O
Biological Activity: TAPS is an aminosulfonate-based lysozyme stabilizer and connexin channel inhibitor. TAPS maintains the native structure of lysozyme in aqueous solution at pH 7.0 and significantly protects it from heat-induced denaturation. TAPS directly inhibits the activity of heteromeric connexin 32/connexin 26 channels (Cx32/Cx26) via its protonated form, and this inhibitory effect is dependent on the presence of connexin 26. TAPS reduces connexin channel-mediated solute exchange in a recombinant liposome system, resulting in a decreased degree of liposome density shift in transport-specific separation assays. TAPS is a critical compound for investigating the structure and function of connexin channels[1][2].
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TAPS | 98.0% | TAPS is an aminosulfonate-based lysozyme stabilizer and connexin channel inhibitor. TAPS maintains the native structure of lysozyme in aqueous solution at pH 7.0 and significantly protects it from heat-induced denaturation. TAPS directly inhibits the activity of heteromeric connexin 32/connexin 26 channels (Cx32/Cx26) via its protonated form, and this inhibitory effect is dependent on the presence of connexin 26. TAPS reduces connexin channel-mediated solute exchange in a recombinant liposome system, resulting in a decreased degree of liposome density shift in transport-specific separation assays. TAPS is a critical compound for investigating the structure and function of connexin channels. | ||||||||||||||||||||
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- [1]. Pannuru P, et al. The effects of biological buffers TRIS, TAPS, TES on the stability of lysozyme. Int J Biol Macromol. 2018;112:720-727. [Content Brief]
- [2]. Bevans C G, et al. Regulation of connexin channels by pH: direct action of the protonated form of taurine and other aminosulfonates[J]. Journal of Biological Chemistry, 1999, 274(6): 3711-3719.
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