Search Result

Results for "

Cys58

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (2) Aminopeptidase (1) Apoptosis (1) Bacterial (6) Biochemical Assay Reagents (4) Calcium Channel (3) Collagen (2) Endothelin Receptor (2) Epigenetic Reader Domain (3) Guanylate Cyclase (2) Histamine Receptor (1) Influenza Virus (1) Kallikrein (2) mAChR (1) MCHR1 (GPR24) (2) Melanocortin Receptor (2) Molecular Glues (2) PCSK9 (1) Potassium Channel (4) PROTACs (1) Ras (3) Ser/Thr Protease (1) Sodium Channel (2) Somatostatin Receptor (1) TGF-β Receptor (2) Transmembrane Glycoprotein (1) TRP Channel (1) Urotensin Receptor (2)
By Research Areas:	Cancer (14) Cardiovascular Disease (13) Endocrinology (3) Infection (8) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (12)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (2)

Aminopeptidase (1)

Apoptosis (1)

Bacterial (6)

Biochemical Assay Reagents (4)

Calcium Channel (3)

Collagen (2)

Endothelin Receptor (2)

Epigenetic Reader Domain (3)

Guanylate Cyclase (2)

Histamine Receptor (1)

Influenza Virus (1)

Kallikrein (2)

mAChR (1)

MCHR1 (GPR24) (2)

Melanocortin Receptor (2)

Molecular Glues (2)

PCSK9 (1)

Potassium Channel (4)

PROTACs (1)

Ras (3)

Ser/Thr Protease (1)

Sodium Channel (2)

Somatostatin Receptor (1)

TGF-β Receptor (2)

Transmembrane Glycoprotein (1)

TRP Channel (1)

Urotensin Receptor (2)

By Research Areas:

Cancer (14)

Cardiovascular Disease (13)

Endocrinology (3)

Infection (8)

Inflammation/Immunology (6)

Metabolic Disease (4)

Neurological Disease (12)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0017

Aprotinin Maximum Cited Publications 31 Publications Verification	Influenza Virus Ser/Thr Protease	Cardiovascular Disease Cancer
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

HY-P1275

Tertiapin-Q 3 Publications Verification	Potassium Channel	Cardiovascular Disease
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

HY-172615

AMPTX-1	Molecular Glues Epigenetic Reader Domain	Cancer
AMPTX-1 is a selective, orally active, covalent reversible BRD9 molecular glue degrader with a DC₅₀ of 0.05 nM. AMPTX-1 selectively recruits BRD9 to the E3 ligase DCAF16. AMPTX-1 forms a ternary complex with BRD9 and a reversible covalent adduct with Cys58 on the surface of DCAF16. AMPTX-1 mediates BRD9 degradation via the proteasome and Cullin RING E3 ligase pathways. AMPTX-1 can be used in the research of solid tumors and hematological malignancies .

HY-153385

TMX1	Molecular Glues Epigenetic Reader Domain	Cancer
TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the BRD4-TMX1-DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4_DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity .

HY-P5322

Thrombospondin (TSP-1)-derived CD36 binding motif	Transmembrane Glycoprotein	Cardiovascular Disease Cancer
Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer .

HY-P10486

AIP-II	Bacterial	Infection
AIP-II is a cyclic peptide signaling molecule for quorum sensing, which is produced by Staphylococcus aureus. AIP-II potently inhibits AgrC-III in Methicillin (HY-121544)-resistant type III Staphylococcus aureus strain AH1747, with an IC50 of 0.532 nM. AIP-II binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus .

HY-106302

Duramycin Moli1901; Lancovutide	Bacterial	Infection Inflammation/Immunology
Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .

HY-P3561A

Agouti-related Protein (AGRP) (83-132) Amide (human) TFA	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake .

HY-12537

Peptide 401	Histamine Receptor 5-HT Receptor	Inflammation/Immunology Endocrinology
Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

HY-P5174

MitTx	Sodium Channel	Neurological Disease
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC₅₀ values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation .

HY-P5533

CRT	Biochemical Assay Reagents	Cancer
CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency .

HY-P1164A

Urotensin II (114-124), human TFA	Urotensin Receptor	Cardiovascular Disease
Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

HY-P5792

Atrial natriuretic peptide (3-28) (human) ANP (3-28) (human)	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriuretic peptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis .

HY-108814A

Ecallantide TFA 2 Publications Verification DX-88 TFA	Kallikrein	Cardiovascular Disease
Ecallantide (DX-88) TFA is a specific recombinant plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide may be used to prevent acute attacks of angioedema .

HY-P3282

MM 419447	Guanylate Cyclase	Metabolic Disease
MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C) .

HY-17584A

Linaclotide acetate 2 Publications Verification	Guanylate Cyclase	Cancer
Linaclotide acetate is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

HY-P3269

Calciseptine	Calcium Channel	Cardiovascular Disease
Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC₅₀ value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases_[1].

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) TFA	MCHR1 (GPR24)	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P5011

Cortistatin-17 (human)	Somatostatin Receptor	Inflammation/Immunology Cancer
Cortistatin-17 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain .

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P3277

KRpep-2d	Ras	Cancer
KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research .

HY-P5089A

Enterotoxin STp (E. coli) TFA	Biochemical Assay Reagents	Infection
Enterotoxin STp (E. coli) TFA is a heat-stable enterotoxin that can be used in vaccine research .

HY-P5089

Enterotoxin STp (E. coli)	Biochemical Assay Reagents	Infection
Enterotoxin STp (E. coli) is a heat-stable enterotoxin that can be used in vaccine research .

HY-P11071

PCSK9 Inhibitor, EGF-A	PCSK9	Cardiovascular Disease
PCSK9 Inhibitor, EGF-A is a PCSK9 inhibitor. PCSK9 Inhibitor, EGF-A is residues 293-334 of the EGF-A domain of the low-density lipoprotein (LDL) receptor. PCSK9 Inhibitor, EGF-A can prevent PCSK9-induced intracellular LDLR degradation. PCSK9 Inhibitor, EGF-A can be used in the study of hypercholesterolemia and premature atherosclerosis .

HY-P5081

Endotrophin (Mus musculus)	TGF-β Receptor Collagen	Inflammation/Immunology
Endotrophin (Mus musculus) is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice. Endotrophin (Mus musculus) activates the TGF-β signaling pathway and reduces the expression of hormone-sensitive lipase. Endotrophin (Mus musculus) induces adipogenesis, lipid accumulation, fibrosis, inflammation, angiogenesis, adipose tissue expansion, epithelial-mesenchymal transition, and insulin resistance; it also induces Cisplatin (HY-17394) resistance in cancer cells. Endotrophin (Mus musculus) can be used in research related to metabolic diseases such as obesity and type 2 diabetes, as well as cancers such as breast cancer .

HY-P10654

RhTx	TRP Channel	Neurological Disease
RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception .

HY-108814

Ecallantide DX-88	Kallikrein	Cardiovascular Disease
Ecallantide (DX-88) is a specific plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema .

HY-P1719

Recanaclotide IW-9179	Biochemical Assay Reagents	Others
Recanaclotide can be studied in research on gastroparesis, functional dyspepsia and gastrointestical disorders.

HY-P3561

Agouti-related Protein (AGRP) (83-132) Amide (human)	Melanocortin Receptor	Neurological Disease
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake .

HY-P5175

Muscarinic toxin 7	mAChR	Neurological Disease
Muscarinic toxin 7 is a peptide toxin with selective and noncompetitive antagonism at the muscarinic M1 receptor .

HY-P1164

Urotensin II (114-124), human	Urotensin Receptor	Cardiovascular Disease
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

HY-P4205

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

HY-183575

JQ1-JX5	PROTACs Epigenetic Reader Domain	Cancer
JQ1-JX5 is a DCAF16-based BRD4 PROTAC degrader. JQ1-JX5 covalently modifies Cys58 of DCAF16, promotes ternary complex formation with BRD4, enables BRD4 ubiquitination and proteasomal degradation. JQ1-JX5 induces time-dependent degradation of BRD4 long and short isoforms in AGS cells with DC₅₀ of 43.97 and 16.77 nM. JQ1-JX5 can be used for the research of cancer, such as acute myeloid leukemia .

HY-P5796

FS-2	Calcium Channel	Neurological Disease
FS-2 is a potent and specific L-type Ca_V channel inhibitor. FS-2 inhibits high K ⁺ or glucose induced L-type Ca ²⁺ influx in RIN beta cells .

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

HY-P1442

AdTx1	Adrenergic Receptor	Cancer
AdTx1 is a selective α1A-adrenoceptor antagonist (K_i: 0.35 nM). AdTx1 can be used for research of benign prostatic hyperplasia .

HY-P1018

IRL 1038	Endothelin Receptor	Neurological Disease
IRL 1038 is an endothelin B receptor selective antagonist with a K_i of 6-11 nM .

HY-P3707

Tumor targeted pro-apoptotic peptide	Apoptosis	Cancer
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice .

HY-P5071

EcAMP3	Bacterial	Infection
EcAMP3 is a hairpin-like peptide. EcAMP3 has antifungal and antibacterial activity. EcAMPs precursor family contains seven identical cysteine motifs: C1XXXC2(11–13)C3XXXC4 .

HY-P4869

Biotin-KRpep-2d acetate	Ras	Others
Biotin-KRpep-2d acetate is a biotin-labeled KRpep-2d (HY-P3277) .

HY-P3277A

KRpep-2d TFA	Ras	Cancer
KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research .

HY-P5887

Tertiapin-RQ	Potassium Channel	Neurological Disease
Tertiapin-RQ is an inward rectifier K ⁺ channel blocker peptide with antidepressive effect .

HY-P1403

Tertiapin LQ	Potassium Channel	Others
Tertiapin LQ is a specific and reversible renal outer medullary potassium ROMK1 (Kir1.1) channel inhibitor .

HY-P5648

PhD2	Bacterial	Infection
PhD2 is an antimicrobial peptide derived from monkey white blood cells. PhD2 has activity against bacteria and fungus Candida albicans .

HY-P5649

PhD3	Bacterial	Infection
PhD3 is an antimicrobial peptide derived from monkey white blood cells. PhD3 has activity against bacteria and fungus Candida albicans .

HY-P5626

Seabream hepcidin	Bacterial	Infection
Seabream hepcidin is an antimicrobial peptide with anti-bacterial (V.anguillarum), fungal (S.cerevisiae) and viral hemorrhagic septicemia virus activity .

HY-P5920

Urotoxin α-KTx 6.21	Potassium Channel	Neurological Disease
Urotoxin is an inhibitor of the potassium channel. Urotoxin has a selective affinity for hKv1.2 channel .

HY-P5081A

Endotrophin (Mus musculus) TFA	TGF-β Receptor Collagen	Inflammation/Immunology
Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice. Endotrophin (Mus musculus) TFA activates the TGF-β signaling pathway and reduces the expression of hormone-sensitive lipase. Endotrophin (Mus musculus) TFA induces adipogenesis, lipid accumulation, fibrosis, inflammation, angiogenesis, adipose tissue expansion, epithelial-mesenchymal transition, and insulin resistance; it also induces Cisplatin (HY-17394) resistance in cancer cells. Endotrophin (Mus musculus) TFA can be used in research related to metabolic diseases such as obesity and type 2 diabetes, as well as cancers such as breast cancer .

HY-P3269A

Calciseptine TFA	Calcium Channel	Cardiovascular Disease
Calciseptine TFA, a polypeptide found in black mamba venom, is a selcetive Cav1.2 L-type calcium channel inhibitor with an IC₅₀ of 92 nM. Calciseptine TFA binds to the pore domain shoulder at repeats III and IV of Cav1.2, stabilizing an inactivated conformation. Calciseptine TFA exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the research of cardiovascular diseases .

Cat. No.	Product Name	Target	Research Area