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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
Cys58
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "Cys58" in MCE Product Catalog:
32
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3
3 Cited Publications
Cat. No.: HY-P1275
CAS No.: 910044-56-3
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2
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2
2 Cited Publications
Cat. No.: HY-17584A
CAS No.: 851199-60-5
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Cat. No.: HY-172615
CAS No.: 3033019-04-1
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AMPTX-1 is a selective, orally active, covalent reversible BRD9 molecular glue degrader with a DC50 of 0.05 nM. AMPTX-1 selectively recruits BRD9 to the E3 ligase DCAF16. AMPTX-1 forms a ternary complex with BRD9 and a reversible covalent adduct with Cys58 on the surface of DCAF16. AMPTX-1 mediates BRD9 degradation via the proteasome and Cullin RING E3 ligase pathways. AMPTX-1 can be used in the research of solid tumors and hematological malignancies .
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TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the BRD4-TMX1-DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity .
Cat. No.: HY-P10486
CAS No.: 200010-31-7
Cat. No.: HY-P5322
CAS No.: 138849-26-0
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Cat. No.: HY-P3561A
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Cat. No.: HY-P5174
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Cat. No.: HY-P5533
CAS No.: 2414254-70-7
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Cat. No.: HY-P1164A
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Cat. No.: HY-P5792
CAS No.: 102686-43-1
Synonyms: ANP (3-28) (human)
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Cat. No.: HY-P3282
CAS No.: 1092457-78-7
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Cat. No.: HY-P3269
CAS No.: 178805-91-9
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Cat. No.: HY-P1525
CAS No.: 87218-84-6
Synonyms: MCH (salmon)
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Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Cat. No.: HY-P1525A
Synonyms: MCH (salmon) TFA
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Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Cat. No.: HY-P5011
CAS No.: 189450-19-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
