200010-31-7
Chemical Structure
AIP-II
- CAS No.: 200010-31-7
- Formula:C38H58N10O12S
- Molecular Weight:878.99
InChIKey: GOMDIOPXFUESDK-NWHYMTRRSA-N
SMILES: O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSC1=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC(CN)=O)=O)=O)=O)=O)CO)=O)CO)=O)CC(C)C)N[C@H]1CC2=CC=CC=C2
Biological Activity: AIP-II is a cyclic peptide signaling molecule for quorum sensing, which is produced by Staphylococcus aureus. AIP-II potently inhibits AgrC-III in Methicillin (HY-121544)-resistant type III Staphylococcus aureus strain AH1747, with an IC50 of 0.532 nM. AIP-II binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AIP-II | 98.04% | AIP-II is a cyclic peptide signaling molecule for quorum sensing, which is produced by Staphylococcus aureus. AIP-II potently inhibits AgrC-III in Methicillin (HY-121544)-resistant type III Staphylococcus aureus strain AH1747, with an IC50 of 0.532 nM. AIP-II binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus. | ||||||||||||||||||||
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References
- [1]. Vasquez JK, et al. Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors. Chembiochem. 2017;18(4):413-423. [Content Brief]
- [2]. Tal-Gan Y, et al. Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus. J Am Chem Soc. 2013;135(49):18436-18444. [Content Brief]
