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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
DMT1
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "DMT1" in MCE Product Catalog:
3
3 Cited Publications
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DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia [1].
3
3 Cited Publications
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DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo [1].
1
1 Cited Publications
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TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 (IC50=18 nM), PHD2 (Ki=5.3 nM), and PHD3 (IC50=63 nM), and targets monkey PHD2 with an IC50 of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFα, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia [1] .
Cat. No.: HY-P5131
CAS No.: 255861-98-4
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Cat. No.: HY-124703
CAS No.: 65004-42-4
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Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM [1].
Cat. No.: HY-RS03828
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DMRT1 Human Pre-designed siRNA Set A contains three designed siRNAs for DMRT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27154
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Slc11a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc11a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P81481A
Synonyms: DMT1; DMRT1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1
Cat. No.: HY-RS12995
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SLC11A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC11A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P84933
Synonyms: DCT 1 antibody;
dct-1 antibody;
DCT1 antibody;
Divalent cation transporter 1 antibody;
Divalent metal transporter 1 antibody;
DMT 1 antibody;
DMT-1 antibody;
DMT1 antibody;
FLJ37416 antibody;
Natural resistance associated macrophage protein 2 antibody;
Natural resistance-associated macrophage protein 2 antibody;
NRAM2_HUMAN antibody;
NRAMP 2 antibody;
NRAMP2 antibody;
OK/SW-cl.20 antibody;
Slc11a2 antibody;
Solute carrier family 11 (proton coupled divalent metal ion transporters) member 2 antibody;
Solute carrier family 11 member 2 antibody
Cat. No.: HY-P702017
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC11A2; Natural resistance-associated macrophage protein 2; NRAMP 2; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; Solute carrier family 11 member 2
Cat. No.: HY-RS20644
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Slc11a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc11a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS02641
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CHMP2B Human Pre-designed siRNA Set A contains three designed siRNAs for CHMP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-201025
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(1R,3S,4S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
