1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

TP0463518 

Cat. No.: HY-112144
Handling Instructions

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM.

For research use only. We do not sell to patients.

TP0463518 Chemical Structure

TP0463518 Chemical Structure

CAS No. : 1558021-37-6

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3157 mL 11.5786 mL 23.1573 mL
5 mM 0.4631 mL 2.3157 mL 4.6315 mL
10 mM 0.2316 mL 1.1579 mL 2.3157 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

431.83

Formula

C₂₀H₁₈ClN₃O₆

CAS No.

1558021-37-6

SMILES

ClC(C=C1)=CC=C1OC2=NC=C(CN3C(C(C(NCC(O)=O)=O)=C(O)CC3)=O)C=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
TP0463518
Cat. No.:
HY-112144
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TP0463518

Cat. No.: HY-112144