DMRT1 Antibody (YA1226)(PBS only)

Cat. No.: HY-P81481A: Data Sheet User Guide for Antibodies
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DMRT1 Antibody (YA1226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DMRT1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DMRT1 Antibody (YA1226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DMRT1.

Host

Rabbit

Molecular Weight

Predicted band size: 39 kDa;

Observed band size: 34 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9Y5R6

Gene ID

1761 [NCBI]

Immunogen

A synthesized peptide derived from human DMRT1

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity)

Subcellular Localization：Nucleus

Expression：
Tissue_specificity:Testis-specific. Expressed in prostate cancer (at protein level)

Isoforms & Post-Translational Modification：Q9Y5R6 has 3 isomers: Q9Y5R6-1: 39473 Da (predicted); Q9Y5R6-2: 28690 Da (predicted); Q9Y5R6-3: 18325 Da (predicted).

Research Field

Epigenetics and Nuclear Signaling

Synonyms

DMT1; DMRT1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1

Documentation

User Guide for Antibodies (1077 KB)