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Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

DNA aptamer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Apoptosis (1) c-Kit (1) Cholecystokinin Receptor (1) Fluorescent Dye (3) G Protein-coupled Receptor Kinase (GRK) (1) Influenza Virus (1) Mixed Lineage Kinase (1) Mucin (1) NO Synthase (1) PDGFR (1) PROTACs (2) RIP kinase (1) Thrombin (2) TNF Receptor (2) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1)
Oligonucleotides:	Aptamers (21)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Oligonucleotides

Targets Recommended: DNA-PK DNA Glycosylase DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148826

Rovunaptabin ARC 183; BC 007	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
Rovunaptabin (ARC 183) is an aptamer, a single-stranded DNA molecule composed of 15 deoxynucleotides. It acts as a broad-spectrum neutralizer of pathogenic G-protein-coupled receptor autoantibodies. Rovunaptabin can be used in research related to cardiomyopathy and pulmonary hypertension .

HY-160066

*SYL3C aptamer* sodium**	Transmembrane Glycoprotein	Cancer
SYL3C aptamer sodium is a DNA aptamer that targets epithelial cell adhesion molecule (EpCAM) on the surface of cancer cells. SYL3C aptamer sodium targets a variety of human cancer cell lines including MDA-MB-231, Kato III, HT-29, T47D and SW480. The K_d values of SYL3C aptamer sodium against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III are 38 nM and 67 nM, respectively. SYL3C aptamer sodium possesses stability, high binding affinity and selectivity, and can be used for targeted cancer cell imaging and circulating tumor cell detection .

HY-W073524

DFAME	Fluorescent Dye	Others
DFAME is a red fluorophore (Ex = 508 nm, Em = 641 nm). DFAME binds to Beetroot and Corn (dimeric fluorescent RNA aptamers) to form Beetroot-DFAME (K_d = 460 nM) and Corn-DFAME (K_d = 3600 nM). Beetroot-DFAME and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .

HY-177119

ZBP1 Covalent PROTAC-1	PROTACs RIP kinase Mixed Lineage Kinase	Infection Inflammation/Immunology
ZBP1 Covalent PROTAC-1 is a covalent Z-DNA binding protein 1 ZBP1 PROTAC degrader, with its DC₅₀ being 25.69 nM. ZBP1 Covalent PROTAC-1 integrates the ligand that recruits the VHL E3 ubiquitin ligase and the DNA aptamer (Aptamer Z3) with the specific Zα domain that can bind to ZBP1, which has a high affinity (K_D = 2.71 nM) with ZBP1. After degrading ZBP1, the phosphorylation levels of downstream signaling molecules RIPK3 and MLKL significantly decrease. ZBP1 Covalent PROTAC-1, encapsulated by nano-liposomes, significantly improves the survival rate of mice infected with influenza A virus (IAV) after administration via the trachea .

HY-160596

5-Formyl-dCTP lithium 5-Formyl-deoxycytidine lithium	DNA/RNA Synthesis	Others
5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity .

HY-177406

VR11 aptamer	TNF Receptor Apoptosis NO Synthase	Inflammation/Immunology
VR11 aptamer is a DNA-based TNF-α inhibitor with a K_D of 7.0 nM. VR11 aptamer prevents TNFα-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research .

HY-160045

*AP1153 aptamer* sodium**	Cholecystokinin Receptor	Cancer
AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo .

HY-177807

*DNMT1 aptamer* sodium**	DNA Methyltransferase	Cancer
DNMT1 aptamer sodium is a DNA aptamer for binding and inhibition of DNA methyltransferase 1 (DNMT1).

HY-160060

*MA3 aptamer* sodium**	Mucin	Cancer
MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .

HY-119782

L-Argininamide	Fluorescent Dye	Others
L-Argininamide is a hydrophilic amino acid derivative and can be used as a compound for ligand binding DNA aptamers. L-Argininamide has the potential for fluorescent aptasensors development .

HY-177804

*Thrombin aptamer* sodium**	Thrombin	Inflammation/Immunology
Thrombin aptamer is a 11mer-DNA aptamer that targets thrombin. Thrombin aptamer inhibites thrombin-catalysed fibrin-clot formation in vitro

HY-177637

*H5N1 aptamer* sodium**	Influenza Virus	Infection
H5N1 aptamer sodium is a DNA aptamer targeted to H5N1 Avian Influenza Virus.

HY-177821

*CD117/c-Kit aptamer* sodium**	c-Kit	Cancer
CD117/c-Kit aptamer sodium is a single-strand DNA aptamer specific for the biomarker CD117, which is highly expressed on acute myeloid leukemia (AML) cells.

HY-160063

*SW1 aptamer* sodium**	Fluorescent Dye DNA Alkylator/Crosslinker	Cancer
SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .

HY-177823

C2NP sodium	TNF Receptor	Cancer
C2NP sodium is a single-strand DNA aptamer that targets CD30. The multivalent C2NP is able to induce oligomerization of CD30 receptors and, in effect, activate downstream signaling, which led to apoptosis of anaplastic large cell lymphoma (ALCL) cells.

HY-160048

PEG40K unconjugated/naked AX102 sodium	PDGFR	Cancer
PEG40K unconjugated/naked AX102 sodium is AX102 without PEG40K conjugation. AX102 is a DNA oligonucleotide aptamer for platelet-derived growth factor PDGF-B. AX102 is 34 bases in length, selectively binds platelet-derived growth factor B (PDGF-B), and causes tumor vessel regression .

HY-185102

ZBP1 PROTAC-1	PROTACs	Cancer
ZBP1 PROTAC-1 (2a+aptamer) is a *Z-DNA* binding protein 1 (ZBP1) PROTAC*. ZBP1 PROTAC-1 consists of a DNA* aptamer (specifically binds to ZBP1) and an E3 enzyme-recruiting unit. ZBP1 PROTAC-1 combines the high specificity of DNA aptamers with the degradation-inducing capabilities of PROTACs, providing a powerful tool for targeted protein degradation .

HY-148826A

Rovunaptabin sodium ARC 183 sodium; BC 007 sodium	Thrombin	Cardiovascular Disease
Rovunaptabin sodium (ARC 183 sodium) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.

DFAME	Fluorescent Dyes
DFAME is a red fluorophore (Ex = 508 nm, Em = 641 nm). DFAME binds to Beetroot and Corn (dimeric fluorescent RNA aptamers) to form Beetroot-DFAME (K_d = 460 nM) and Corn-DFAME (K_d = 3600 nM). Beetroot-DFAME and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .

Cat. No.	Product Name	Target	Research Area

HY-119782

L-Argininamide	Fluorescent Dye	Others
L-Argininamide is a hydrophilic amino acid derivative and can be used as a compound for ligand binding DNA aptamers. L-Argininamide has the potential for fluorescent aptasensors development .

Cat. No.	Product Name		Classification

HY-148826

Rovunaptabin ARC 183; BC 007		Aptamers
Rovunaptabin (ARC 183) is an aptamer, a single-stranded DNA molecule composed of 15 deoxynucleotides. It acts as a broad-spectrum neutralizer of pathogenic G-protein-coupled receptor autoantibodies. Rovunaptabin can be used in research related to cardiomyopathy and pulmonary hypertension .

HY-160066

*SYL3C aptamer* sodium**		Aptamers
SYL3C aptamer sodium is a DNA aptamer that targets epithelial cell adhesion molecule (EpCAM) on the surface of cancer cells. SYL3C aptamer sodium targets a variety of human cancer cell lines including MDA-MB-231, Kato III, HT-29, T47D and SW480. The K_d values of SYL3C aptamer sodium against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III are 38 nM and 67 nM, respectively. SYL3C aptamer sodium possesses stability, high binding affinity and selectivity, and can be used for targeted cancer cell imaging and circulating tumor cell detection .

HY-160050

*CD63-1 aptamer* sodium**		Aptamers
CD63-1 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 38.71 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .

HY-177406

VR11 aptamer		Aptamers
VR11 aptamer is a DNA-based TNF-α inhibitor with a K_D of 7.0 nM. VR11 aptamer prevents TNFα-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research .

HY-160045

*AP1153 aptamer* sodium**		Aptamers
AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo .

HY-177807

*DNMT1 aptamer* sodium**		Aptamers
DNMT1 aptamer sodium is a DNA aptamer for binding and inhibition of DNA methyltransferase 1 (DNMT1).

HY-160060

*MA3 aptamer* sodium**		Aptamers
MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .

HY-177811

*HE4 aptamer* sodium**		Aptamers
HE4 aptamer sodium is a DNA aptamer with affinity for the ovarian cancer biomarker HE4.

HY-177804

*Thrombin aptamer* sodium**		Aptamers
Thrombin aptamer is a 11mer-DNA aptamer that targets thrombin. Thrombin aptamer inhibites thrombin-catalysed fibrin-clot formation in vitro

HY-177637

*H5N1 aptamer* sodium**		Aptamers
H5N1 aptamer sodium is a DNA aptamer targeted to H5N1 Avian Influenza Virus.

HY-177822

*CD4 aptamer* sodium**		Aptamers
CD4 aptamer sodium is a single-strand DNA aptamer that targets CD4. It significantly blocks the interaction between viral gp120 and CD4-expressing cells

HY-177821

*CD117/c-Kit aptamer* sodium**		Aptamers
CD117/c-Kit aptamer sodium is a single-strand DNA aptamer specific for the biomarker CD117, which is highly expressed on acute myeloid leukemia (AML) cells.

HY-177803

*Protein C aptamer* sodium**		Aptamers
Protein C aptamer sodium is a 44mer-DNA aptamer that the anticoagulant functions of activated protein C. Activated protein C (APC) is a serine protease with anticoagulant, anti-inflammatory, and cytoprotective properties.

HY-160063

*SW1 aptamer* sodium**		Aptamers
SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .

HY-160051

*CD63-2 aptamer* sodium**		Aptamers
CD63-2 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 78.43 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .

HY-177823

C2NP sodium		Aptamers
C2NP sodium is a single-strand DNA aptamer that targets CD30. The multivalent C2NP is able to induce oligomerization of CD30 receptors and, in effect, activate downstream signaling, which led to apoptosis of anaplastic large cell lymphoma (ALCL) cells.

HY-160048

PEG40K unconjugated/naked AX102 sodium		Aptamers
PEG40K unconjugated/naked AX102 sodium is AX102 without PEG40K conjugation. AX102 is a DNA oligonucleotide aptamer for platelet-derived growth factor PDGF-B. AX102 is 34 bases in length, selectively binds platelet-derived growth factor B (PDGF-B), and causes tumor vessel regression .

HY-177870

Sgc8c Aptamer		Aptamers
Sgc8c Aptamer is a single-stranded DNA aptamer targeting protein tyrosine kinase 7 (PTK7) with K_d of 1.03-11.73 nM for human, mice, rat and monkey. Sgc8c Aptamer can be used to synthesize aptamer-drug conjugates and can be used for cancer research .

HY-177818

B23 sodium		Aptamers
B23 sodium is a DNA aptamer that bind specifically to luteinising hormone (LH).

HY-148826A

Rovunaptabin sodium ARC 183 sodium; BC 007 sodium		Aptamers
Rovunaptabin sodium (ARC 183 sodium) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.

HY-177814

LJM-3064 sodium		Aptamers
LJM-3064 sodium is a guanosine-rich 40-mer DNA aptamer that targets myelin. LJM-3064 mediates remyelination in the Theiler's murine encephalomyelitis virus mouse model of multiple sclerosis.

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