5-Formyl-dCTP lithium  (Synonyms: 5-Formyl-deoxycytidine lithium)

5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity^[1][2].

5-Formyl-dCTP lithium exhibits enriched, specific binding to Con A (K_d,eff = 20 nM) with minimal binding to PSA (K_d,eff > 1 μM) after three rounds of two-color click-PD screening^[1].
5-Formyl-dCTP lithium (10-250 μM) is hydrolysed by purified recombinant human DCTPP1 with high efficiency, exhibiting a K_m of 9.2 μM, the lowest substrate affinity reported for the enzyme, and a specificity constant of 322,000/M·s^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

518.90

C₁₀H₁₂Li₄N₃O₁₄P₃

2409156-19-8

O=CC1=CN([C@@H](C[C@@H]2O)O[C@@H]2COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)C(N=C1N)=O

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• [1]. Gordon CKL, et al. Click-Particle Display for Base-Modified Aptamer Discovery. ACS Chem Biol. 2019;14(12):2652-2662.  [Content Brief]

  [2]. Requena CE, et al. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. Biochem J. 2014;459(1):171-180.  [Content Brief]