9 Results for "

Death Receptor 5

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "Death Receptor 5" in MCE Product Catalog:

Cat. No.: HY-P99260
CAS No.: 896731-82-1
Synonyms: AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody

Target:  

TNF Receptor

Research Areas:  

Cancer

Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .
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Cat. No.: HY-P99270
CAS No.: 918127-53-4
Synonyms: CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody

Target:  

Apoptosis

Research Areas:  

Cancer

Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .
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Cat. No.: HY-P99470
CAS No.: 2109730-69-8
Synonyms: GEN1029

Target:  

TNF Receptor Apoptosis

Research Areas:  

Cancer

Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects .
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Cat. No.: HY-122578
CAS No.: 922150-12-7
Purity:  99.93%
Target:  

MDM-2/p53

Research Areas:  

Cancer

P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 R175H, p53 R248W and p53 R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research .
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Cat. No.: HY-N1524
CAS No.: 465-74-7
Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD) .
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Cat. No.: HY-P990901
CAS No.: 2796349-94-3
Synonyms: IGM-8444

Target:  

TNF Receptor Apoptosis

Research Areas:  

Cancer

Aplitabart (IGM-8444) is a pentameric IgM death receptor 5 (DR5) agonist antibody with a KD of 85 nM and an apparent affinity of 11 pM. Aplitabart induces DR5 multimerization, thereby triggering cancer cell apoptosis via the extrinsic apoptotic pathway apoptosis. Aplitabart is applicable to cancer-related research such as colorectal cancer and gastric cancer .
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Cat. No.: HY-103130A
CAS No.: 54635-62-0
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

EMD386088 free base is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 free base induces cell death. EMD386088 free base regulates the activity of ERK1/2. EMD386088 free base has the potential for the research of alzheimer's disease (AD) and schizophrenia .
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Cat. No.: HY-P85577
Synonyms: Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing Receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL Receptor 2; Death domain containing Receptor for TRAIL/Apo 2L; Death domain containing Receptor for TRAIL/Apo2L; Death Receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; OTTHUMP00000123492; OTTHUMP00000123493; p53 regulated DNA damage inducible cell Death Receptor; killer; p53 regulated DNA damage inducible cell Death Receptor; killer; TNF related apoptosis inducing ligand Receptor 2; TNF related apoptosis inducing ligand Receptor 2; TNF-related apoptosis-inducing ligand Receptor 2; TNFRSF10B; TR10B_HUMAN; TRAIL R2; TRAIL Receptor 2; TRAIL-R2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor Receptor like protein ZTNFR9; Tumor necrosis factor Receptor like protein ZTNFR9; Tumor necrosis factor Receptor superfamily member 10b; Tumor necrosis factor Receptor superfamily, member 10b; ZTNFR9.

Host:  

Mouse

Application:  

WB, ICC/IF

Reactivity:  

Human, Mouse

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Cat. No.: HY-P80109
Synonyms: CD262, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186, TNFRSF10B, Tumor necrosis factor Receptor superfamily member 10B, Death Receptor 5, TNF-related apoptosis-inducing ligand Receptor 2, TRAIL Receptor 2, TRAIL-R2

Host:  

Rabbit

Application:  

WB, IHC-P, FC

Reactivity:  

Human

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