2796349-94-3
2796349-94-3
Chemical Structure
Aplitabart
Synonym(s): IGM-8444
- CAS No.: 2796349-94-3
- Formula:N/A
- Molecular Weight:(871.57 kDa)
SMILES: [Aplitabart]
Biological Activity: Aplitabart (IGM-8444) is a pentameric IgM death receptor 5 (DR5) agonist antibody with a KD of 85 nM and an apparent affinity of 11 pM. Aplitabart induces DR5 multimerization, thereby triggering cancer cell apoptosis via the extrinsic apoptotic pathway apoptosis. Aplitabart is applicable to cancer-related research such as colorectal cancer and gastric cancer[1][2].
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Aplitabart | 97.024% | Aplitabart (IGM-8444) is a pentameric IgM death receptor 5 (DR5) agonist antibody with a KD of 85 nM and an apparent affinity of 11 pM. Aplitabart induces DR5 multimerization, thereby triggering cancer cell apoptosis via the extrinsic apoptotic pathway apoptosis. Aplitabart is applicable to cancer-related research such as colorectal cancer and gastric cancer. | ||||||||||||||||||||
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References
- [1]. Wang BT, et al. Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199. Mol Cancer Ther. 2021;20(12):2483-2494. [Content Brief]
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[2]. Wang BT, et al. The Anti-Tumor Activity of Igm-8444, an Agonistic Death Receptor 5 (DR5) IgM Antibody, Is Sensitized in Combination with Chemotherapy and Bcl-2 Inhibitors in NHL and AML. Blood. 2020 Nov 5;136:43-4.
