2. Apoptosis
  3. TNF Receptor Apoptosis
  4. Aplitabart

Aplitabart  (Synonyms: IGM-8444)

Cat. No.: HY-P990901 Purity: 97.024%
COA
SDS
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Aplitabart (IGM-8444) is a a pentameric IgM DR5 agonist antibody with 10 binding sites specific for DR5. Aplitabart multimerizes DR5 to selectively and potently induce tumor cell apoptosis. Aplitabart can be used for the study of lung cancer, breast cancer, cute myeloid leukemia (AML) and low-grade B-cell non-Hodgkin lymphoma (B-NHL).

For research use only. We do not sell to patients.

CAS No. : 2796349-94-3

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Based on 1 publication(s) in Google Scholar

Aplitabart Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aplitabart (IGM-8444) is a a pentameric IgM DR5 agonist antibody with 10 binding sites specific for DR5. Aplitabart multimerizes DR5 to selectively and potently induce tumor cell apoptosis. Aplitabart can be used for the study of lung cancer, breast cancer, cute myeloid leukemia (AML) and low-grade B-cell non-Hodgkin lymphoma (B-NHL)[1].

Isotype

Human IgM-kappa_Jchain
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

DR5

 

Clinical Trial
Gene ID

8795  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

871.57 kDa

CAS No.
Appearance

Liquid

Color

Colorless to off-white

SMILES

[Aplitabart]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgM-kappa_Jchain
Biological Activity
  • Immobilized TRAIL R2/TNFRSF10B Protein, Human (HY-P72779) can bind Aplitabart. The EC50 for this effect is 201.8 ng/mL.
Purity & Documentation
References
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Aplitabart Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aplitabart2796349-94-3IGM-8444IGM8444IGM 8444TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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