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Results for "

ELOVL6

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12146
    ELOVL6-IN-2
    5+ Cited Publications

    		 ELOVL Metabolic Disease
    ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM .
    ELOVL6-IN-2
  • HY-152947
    ELOVL6-IN-4

    		ELOVL Metabolic Disease
    ELOVL6-IN-4 is a potent, selective, and orally active long chain fatty acid elongase 6 (ELOVL6) inhibitor with IC50s of 79 nM and 94 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-4 shows excellent selectivity over the other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 .
    ELOVL6-IN-4
  • HY-160912
    ELOVL6-IN-5

    		ELOVL Metabolic Disease
    ELOVL6-IN-5 is an orally active and selective elongase enzyme of long-chain fatty acid family 6 (ELOVL6) inhibitor with IC50 values of 85 nM and 38 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-5 shows >60-fold selectivity over other ELOVL family enzymes (ELOVL1, 2, 3, 5) and no effect on other lipid synthesis enzymes like ACC1, ACC2. ELOVL6-IN-5 reduces hepatic fatty acid composition ratio of C18 to C16 in diet-induced obesity (DIO) and KKAy mice. ELOVL6 inhibition by ELOVL6-IN-5 does not improve insulin resistance. ELOVL6-IN-5 can be used for the research of metabolic disease .
    ELOVL6-IN-5
  • HY-139451
    ELOVL6-IN-3

    		ELOVL Neurological Disease
    ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA .
    ELOVL6-IN-3
  • HY-N11011
    Withaphysalin A

    		NF-κB STAT PERK JNK p38 MAPK PGE synthase Interleukin Related TNF Receptor COX Inflammation/Immunology Cancer
    Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE2, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia .
    Withaphysalin A
  • HY-RS04326
    ELOVL6 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ELOVL6 Human Pre-designed siRNA Set A contains three designed siRNAs for ELOVL6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ELOVL6 Human Pre-designed siRNA Set A
    ELOVL6 Human Pre-designed siRNA Set A
  • HY-RS24566
    Elovl6 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Elovl6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Elovl6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Elovl6 Rat Pre-designed siRNA Set A
    Elovl6 Rat Pre-designed siRNA Set A
  • HY-RS18092
    Elovl6 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Elovl6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Elovl6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Elovl6 Mouse Pre-designed siRNA Set A
    Elovl6 Mouse Pre-designed siRNA Set A

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