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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
ERP
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "ERP" in MCE Product Catalog:
11
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1 Cited Publications
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
PSB36 is a highly selective A1 adenosine receptor antagonist, with a Ki of 0.12 nM and a Kd of 0.7 nM. Systemic administration of PSB36 reduces formalin- and Carrageenan (HY-125474)-induced edema in mice and decreases pain-related behaviors, with no local paw activity. PSB36 prolongs the APD90 of rat and human atria, produces a frequency-dependent prolongation of rat atrial ERP, increases the diastolic threshold of rat atria, and shortens the duration of atrial fibrillation episodes. PSB36 can be used in research related to inflammatory pain, inflammatory hyperalgesia, edema and atrial fibrillation .
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1 Cited Publications
Cat. No.: HY-P71917
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERP59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;
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UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness .
Cat. No.: HY-163351
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PDI-IN-2 is a highly selective PDI inhibitor. PDI-IN-2 has an IC50 of 0.63-4.01 μM against human PDI, and exhibits higher targeting specificity compared with ERp57 and ERp72. PDI-IN-2 inhibits platelet aggregation induced by U46619, collagen and tumor cells, and also blocks platelet-promoted tumor cell proliferation as well as the growth of multiple myeloma cells. PDI-IN-2 serves as an important tool reagent for research on multiple myeloma and associated thrombosis .
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Cat. No.: HY-RS04513
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ERP27 Human Pre-designed siRNA Set A contains three designed siRNAs for ERP27 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04514
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ERP29 Human Pre-designed siRNA Set A contains three designed siRNAs for ERP29 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04515
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ERP44 Human Pre-designed siRNA Set A contains three designed siRNAs for ERP44 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20401
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Erp27 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erp27 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25679
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Erp29 Rat Pre-designed siRNA Set A contains three designed siRNAs for Erp29 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-151286
CAS No.: 2812356-72-0
Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin .
Cat. No.: HY-RS04306
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ELK3 Human Pre-designed siRNA Set A contains three designed siRNAs for ELK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16828
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Dusp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dusp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22155
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Elk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Elk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-111245
CAS No.: 872045-91-5
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AZD-1305 is an antiarrhythmic agent and atrial selective sodium channel/potassium channel blocker, which can significantly prolongs action potential duration and reduces excitability, cause atrial selective ERP prolongation and acute termination of atrial fibrillation. AZD1305 can be used for atrial fibrillation research .
Cat. No.: HY-RS10267
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Pdia3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W705705
CAS No.: 203002-58-8
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NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias .
Cat. No.: HY-163735
CAS No.: 609335-29-7
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BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM–PIP2-binding domain with a IC50 value of 8.6 µM (WT SK4). BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the S4–S5 linker. BA6b9 significantly prolongs atrial and atrioventricular effective refractory period (ERP) and reduces atrial fibrillation (AF) induction in rat isolated hearts, which has the potential to be used for the research of arrhythmia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
