1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. UCL 1684 dibromide

UCL 1684 dibromide 

Cat. No.: HY-108579
Handling Instructions

UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness.

For research use only. We do not sell to patients.

UCL 1684 dibromide Chemical Structure

UCL 1684 dibromide Chemical Structure

CAS No. : 199934-16-2

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Description

UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3].

IC50 & Target

Potassium Channel[1]

In Vitro

UCL 1684 (dibromide) (0.5 μM; HEK cells) produces direct atrial-selective inhibition of sodium channel current (INa) and shifts SS inactivation of the cardiac sodium channels. UCL 1684 (dibromide) (0.5 μM) induces PRR, decreases V max, increases DTE, and extends the shortest S1-S1 interval[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

UCL 1684 (dibromide) (3 mg/kg; i.v.) increases wenckebach cycle length to 115.0±5.1 % of baseline value[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

654.44

Formula

C₃₄H₃₀Br₂N₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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UCL 1684 dibromide
Cat. No.:
HY-108579
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