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Isoforms Recommended:	ERRγ

Results for "

ERRγ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (2) Estrogen Receptor/ERR (14) Ligands for Target Protein for PROTAC (1) PPAR (1) Progesterone Receptor (1) PROTACs (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) ROR (1) Smo (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (3) Endocrinology (2) Infection (1) Metabolic Disease (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155673

SLU-PP-332 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease
SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC₅₀ values of 98, 230 and 430 nM for ERRα, ERRβ and *ERRγ*, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function .

HY-15483

DY131 3 Publications Verification GSK 9089	Estrogen Receptor/ERR Smo	Endocrinology Cancer
DY131 (GSK 9089) is a potent and selective *ERRγ* and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ . DY131 also inhibits Smo signaling .

HY-10426

XCT790 Maximum Cited Publications 10 Publications Verification	Estrogen Receptor/ERR Autophagy	Cancer
XCT-790 is a potent and selective inverse agonist for ERRα with an IC₅₀ value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ .

HY-111226

GSK5182 4 Publications Verification	Estrogen Receptor/ERR Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC₅₀ of 79 nM. GSK5182 does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma (HCC) .

HY-139185

PROTAC ERRα Degrader-3 1 Publications Verification	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .

HY-U00425

PROTAC ERRα ligand 1	Ligands for Target Protein for PROTAC Estrogen Receptor/ERR	Metabolic Disease Cancer
PROTAC ERRα ligand 1 is a PROTAC target protein ligand. PROTAC ERRα ligand 1 is an orally active ERRα inverse agonist with IC₅₀ values of 0.6 μM for ERRα. PROTAC ERRα ligand 1 shows no significant activity against a panel of other nuclear receptors, including ERα ^c, ERRγ, ERβ, PPARα, PPARγ, PPARδ, and RXRα. PROTAC ERRα ligand 1 can provide enhanced insulin sensitivity in vivo. PROTAC ERRα ligand 1 can be used for metabolic diseases research, such as type 2 diabetes and obesity .

HY-114411

ERRγ inverse agonist 1	Estrogen Receptor/ERR	Cancer
ERRγ inverse agonist 1 (Compound 12) is a selective *ERRγ* inverse agonist with an IC₅₀ value of 0.040 μM against *ERRγ. ERRγ* inverse agonist 1 inhibits the activity of *ERRγ* at the functional level. ERRγ inverse agonist 1 can be used in the research of anaplastic thyroid cancer .

HY-145848

ERRγ agonist-1	Estrogen Receptor/ERR	Neurological Disease
ERRγ agonist-1 is a potent *ERRγ* agonist. ERRγ agonist-1 increases transcriptional activities of *ERRγ. ERRγ* agonist-1 has the potential for the research of neuropsychological disorders .

HY-W009066

2-Ethylhexyl diphenyl phosphate EHDPP; Octicizer	PPAR Progesterone Receptor Estrogen Receptor/ERR	Endocrinology
2-Ethylhexyl diphenyl phosphate is an organophosphate flame retardants (OPFRs) and a PPARG agonist (EC₂₀: 2.04 µM). 2-Ethylhexyl diphenyl phosphate also inhibits *ERRγ* transcriptional activity (IC₅₀: 1.3 µM). 2-Ethylhexyl diphenyl phosphate upregulates 3β-HSD1, human chorionic gonadotropin (hCG) and progesterone secretion. 2-Ethylhexyl diphenyl phosphate can be used in studies of female reproduction and fetal development .

HY-111226A

(E/Z)-GSK5182	Estrogen Receptor/ERR Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC₅₀ of 79 nM . GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma .

HY-137818

SR19881	Estrogen Receptor/ERR	Cardiovascular Disease
SR19881 is a potent dual agonist of *ERRγ* and ERRβ, with EC₅₀ values of 0.39 and 0.63 μM, respectively .

HY-149833

ERRγ inverse agonist 2	Estrogen Receptor/ERR	Infection Metabolic Disease
ERRγ inverse agonist 2 (compound 19) is a potent and selective *ERRγ* inverse agonist with a K_d value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities .

HY-177011

ERRγ-IN-1	Estrogen Receptor/ERR	Cancer
ERRγ-IN-1 is a *ERRγ* inhibitor with an IC₅₀ of 0.040 μM. ERRγ-IN-1 activates MAPK (p44/p42) and inhibits the activity of *ERRγ. ERRγ-IN-1 significantly increases iodine uptake in anaplastic thyroid carcinoma xenografts and suppresses tumor growth in nude mice. ERR*γ-IN-1 is applicable for the research of anaplastic thyroid carcinoma .

HY-163192

W6134	ROR Apoptosis	Cancer
W6134 is highly potent and selective RORγ covalent inhibitor with an IC₅₀ of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC). W6134 can be used for the research of castration-resistant prostate cancers (CRPC) .

HY-10426R

XCT790 (Standard)	Reference Standards Estrogen Receptor/ERR Autophagy	Cancer
XCT790 (Standard) is the analytical standard of XCT790 (HY-10426). This product is intended for research and analytical applications. XCT-790 is a potent and selective inverse agonist for ERRα with an IC₅₀ value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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ERRγ

Inhibitors & Agonists