95167-41-2
95167-41-2
Chemical Structure
DY131
Synonym(s): GSK 9089
- CAS No.: 95167-41-2
- Formula:C18H21N3O2
- Molecular Weight:311.38
IUPAC Name: (E)-N'-(4-(diethylamino)benzylidene)-4-hydroxybenzohydrazide
InChIKey: WLKOCYWYAWBGKY-CPNJWEJPSA-N
SMILES: O=C(N/N=C/C1=CC=C(N(CC)CC)C=C1)C2=CC=C(O)C=C2
Biological Activity: DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ[1][2]. DY131 also inhibits Smo signaling[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DY131 | 99.22% | DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ. DY131 also inhibits Smo signaling. | ||||||||||||||||||||
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References
- [1]. Yu S, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67(10):4904-14. [Content Brief]
- [2]. Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15(5): 1311-1313. [Content Brief]
- [3]. Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7(6):1040-8. [Content Brief]
Keywords
