95167-41-2
95167-41-2
Chemical Structure
DY131
Synonym(s): GSK 9089
- CAS No.: 95167-41-2
- Formula:C18H21N3O2
- Molecular Weight:311.38
IUPAC Name: (E)-N'-(4-(diethylamino)benzylidene)-4-hydroxybenzohydrazide
InChIKey: WLKOCYWYAWBGKY-CPNJWEJPSA-N
SMILES: O=C(N/N=C/C1=CC=C(N(CC)CC)C=C1)C2=CC=C(O)C=C2
Biological Activity: DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ[1][2]. DY131 also inhibits Smo signaling[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DY131 | 99.22% | DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ. DY131 also inhibits Smo signaling. | ||||||||||||||||||||
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RSVA405 | 99.72% | RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity. | ||||||||||||||||||||
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SR19881 | 99.30% | SR19881 is a potent dual agonist of ERRγ and ERRβ, with EC50 values of 0.39 and 0.63 μM, respectively. | ||||||||||||||||||||
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ERRγ agonist-1 | 98.02% | ERRγ agonist-1 is a potent ERRγ agonist. ERRγ agonist-1 increases transcriptional activities of ERRγ. ERRγ agonist-1 has the potential for the research of neuropsychological disorders. | ||||||||||||||||||||
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RL-0070933 | RL-0070933 is a potent smo cilial modulator with an EC50 value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. | |||||||||||||||||||||
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SCFSkp2-IN-2 | 99.01% | SCFSkp2-IN-2 (Compound AAA-237) is a Skp2 inhibitor with a KD of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities. | ||||||||||||||||||||
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Anticancer agent 100 | Anticancer agent 100 is a derivative of tetracaine with anti-cancer activity and can be used in cancer research. | |||||||||||||||||||||
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Anticancer agent 103 | Anticancer agent 103 (Compound 2k) is a potent anticancer agent. | |||||||||||||||||||||
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SLU-PP-332 | 98.98% | SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function. | ||||||||||||||||||||
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LSD1-IN-30 | 99.03% | LSD1-IN-30 (compound 3) is a potent inhibitor of lysine-specific demethylase 1 (LSD1), with the IC50 value of 0.291 μM. | ||||||||||||||||||||
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GSK-4716 | 99.63% | GSK-4716 is a selective ERRβ/γ agonist. | ||||||||||||||||||||
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References
- [1]. Yu S, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67(10):4904-14. [Content Brief]
- [2]. Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15(5): 1311-1313. [Content Brief]
- [3]. Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7(6):1040-8. [Content Brief]
