ERRγ agonist-1
Based on 1 Customer Validation
ERRγ agonist-1 is a potent ERRγ agonist. ERRγ agonist-1 increases transcriptional activities of ERRγ. ERRγ agonist-1 has the potential for the research of neuropsychological disorders.
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 3098411-72-1
- Formula: C17H21N5O
- Molecular Weight:311.38
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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ERRγ |
ERRγ agonist-1 (compound 5d) (5 μM; 3 days) significantly increases the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT), DAergic neuronal phenotypes (dopaminergic neuronal phenotype) in neuroblastoma SH-SY5Y cells[1].
ERRγ agonist-1 (5 μM; 3 days) induces DAergic neuronal phenotypes via the ERRγ-mediated up-regulation of CREB-signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:5 µM
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Incubation Time:3 days
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Result:Increased the DAergic neuronal-specific markers, TH and DAT in neuroblastoma SH-SY5Y cells.
Chemical Information
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CAS No. 3098411-72-1
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Appearance Solid
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Molecular Weight 311.38
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Formula C17H21N5O
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Color Light yellow to yellow
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SMILES
CCCN(C1=CC=C(C=C1)/C=N/NC(C2=CC=C(N=C2)N)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL (80.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2115 mL | 16.0576 mL | 32.1151 mL | 80.2878 mL |
| 5 mM | 0.6423 mL | 3.2115 mL | 6.4230 mL | 16.0576 mL | |
| 10 mM | 0.3212 mL | 1.6058 mL | 3.2115 mL | 8.0288 mL | |
| 15 mM | 0.2141 mL | 1.0705 mL | 2.1410 mL | 5.3525 mL | |
| 20 mM | 0.1606 mL | 0.8029 mL | 1.6058 mL | 4.0144 mL | |
| 25 mM | 0.1285 mL | 0.6423 mL | 1.2846 mL | 3.2115 mL | |
| 30 mM | 0.1071 mL | 0.5353 mL | 1.0705 mL | 2.6763 mL | |
| 40 mM | 0.0803 mL | 0.4014 mL | 0.8029 mL | 2.0072 mL | |
| 50 mM | 0.0642 mL | 0.3212 mL | 0.6423 mL | 1.6058 mL | |
| 60 mM | 0.0535 mL | 0.2676 mL | 0.5353 mL | 1.3381 mL | |
| 80 mM | 0.0401 mL | 0.2007 mL | 0.4014 mL | 1.0036 mL |
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