ERRγ inverse agonist 2
ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities.
For research use only. We do not sell to patients.
- CAS No.: 324022-01-7
- Formula: C27H21N5O2
- Molecular Weight:447.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERRγ 6.5 μM (Kd) |
ERRγ inverse agonist 2 (1-10 μM; 293T cells) inhibits PGC-1α-dependent transcriptional activity of ERRγ and the inhibitory effect on ERRα and ERRβ is insignificantly weak[1].
ERRγ inverse agonist 2 (10 μM; AML12 cells) inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 324022-01-7
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Molecular Weight 447.49
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Formula C27H21N5O2
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SMILES
O=C(C1=CN(C2=CC=CC=C2)N=C1C3=CC=CC=C3)NC4=CC(N)=CC(OC5=CC=CN=C5)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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