2983540-55-0
Chemical Structure
W6134
- CAS No.: 2983540-55-0
- Formula:C25H23ClN2O4S
- Molecular Weight:482.98
InChIKey: PSNSGPNLXRHGNN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C2=C(C=CC=C2)NC(C=C)=O)C(Cl)=C1)CC3=CC=C(C=C3)S(=O)(CC)=O
Biological Activity: W6134 is highly potent and selective RORγ covalent inhibitor with an IC50 of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC). W6134 can be used for the research of castration-resistant prostate cancers (CRPC)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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W6134 | 99.90% | W6134 is highly potent and selective RORγ covalent inhibitor with an IC50 of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC). W6134 can be used for the research of castration-resistant prostate cancers (CRPC). | ||||||||||||||||||||
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Keywords
