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Isoforms Recommended: EphB
Results for "

EphB4

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Natural
Products

7

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13258A
    NVP-BHG712
    5+ Cited Publications

    BHG712

    		 Ephrin Receptor Cancer
    NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC50 values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively .
    NVP-BHG712
  • HY-16265
    JI-101

    		Ephrin Receptor PDGFR VEGFR Cardiovascular Disease Cancer
    JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ and EphB4 with potent anti-cancer activity.
    JI-101
  • HY-13258
    NVP-BHG712 isomer
    2 Publications Verification

    		 Ephrin Receptor Cancer
    NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4 .
    NVP-BHG712 isomer
  • HY-RS04436
    EPHB4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EPHB4 Human Pre-designed siRNA Set A contains three designed siRNAs for EPHB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EPHB4 Human Pre-designed siRNA Set A
    EPHB4 Human Pre-designed siRNA Set A
  • HY-136895
    AZ12672857

    		Prostaglandin Receptor Cancer
    AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM) .
    AZ12672857
  • HY-15268
    PP487

    		c-Met/HGFR PI3K DNA-PK mTOR Bcr-Abl Src VEGFR EGFR PDGFR Cancer
    PP487 is a dual inhibitor of tyrosine kinase/PI(3)Ks with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used for cancer research .
    PP487
  • HY-RS24229
    Ephb4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ephb4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ephb4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ephb4 Rat Pre-designed siRNA Set A
    Ephb4 Rat Pre-designed siRNA Set A
  • HY-186005
    EPHB4 modulator-1

    		Ephrin Receptor Cancer
    EPHB4 modulator-1 is a EPHB4 modulator.
    EPHB4 modulator-1
  • HY-RS17762
    Ephb4 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ephb4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ephb4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ephb4 Mouse Pre-designed siRNA Set A
    Ephb4 Mouse Pre-designed siRNA Set A
  • HY-155684
    SA-PA

    		PROTACs VEGFR PDGFR Ephrin Receptor Cancer
    SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .
    SA-PA
  • HY-N3634
    Corylifol C

    		EGFR TAM Receptor Tie Cancer
    Corylifol C is a potent protein kinase inhibitor with IC50 valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .
    Corylifol C
  • HY-10654
    EphB4-IN-2

    		Ephrin Receptor Cancer
    EphB4-IN-2 (compound 66) is a tyrosine kinase inhibitor with an IC50 value of 1.6 nM against human EphB4, and exhibits selectivity toward kinases bearing threonine gatekeeper residues. EphB4-IN-2 also has high ligand efficiency .
    EphB4-IN-2
  • HY-185227
    EphB4-IN-1

    		Ephrin Receptor Src Bcr-Abl EGFR Cancer
    EphB4-IN-1 is a selective EphB4 tyrosine kinase inhibitor with IC50 values of 0.16-0.30 μM. EphB4-IN-1 binds to the ATP binding site of EphB4 in a DFG-in conformation, forming four stable intermolecular hydrogen bonds. EphB4-IN-1 also inhibits Src, Abl1, Lck, and EGFR kinases. EphB4-IN-1 inhibits EphB4 autophosphorylation. EphB4-IN-1 can be used for the research of cancer, such as non small cell lung cancer .
    EphB4-IN-1
  • HY-155685
    SA-VA

    		PROTACs VEGFR Ephrin Receptor Apoptosis Cancer
    SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .
    SA-VA
  • HY-171217
    TG-100435

    		Src Bcr-Abl Ephrin Receptor Cancer
    TG-100435 is a multitargeted, orally active protein tyrosine kinase inhibitor, with Ki of 13 to 64 nM for Src, Lyn, Abl, Yes, Lck, and EphB4. TG-100435 plays an important role in cancer research .
    TG-100435
  • HY-16265A
    JI-101 hydrochloride

    		Ephrin Receptor PDGFR VEGFR Cancer
    JI-101 hydrochloride is an orally active angiogenesis inhibitor and anticancer agent with 55% oral bioavailability in Sprague Dawley rats, high permeability, and no P-gp substrate activity .JI-101 hydrochloride modulates angiogenesis signaling pathways in tumor vessel beds, downregulates EphB4, targets EphB4, VEGFR-2, and PDGFR-β, and inhibits multiple stages of tumor angiogenesis .JI-101 hydrochloride exerts activity against cancer cells and xenografts, exhibits mild to moderate inhibition of CYP3A4, and shows stability in pre-clinical and human liver microsomes .JI-101 hydrochloride undergoes rapid oral absorption in Sprague Dawley rats, has extensive tissue distribution with preferred lung uptake, and is excreted via bile with mono- and di-hydroxy metabolites, with feces as the primary elimination route .JI-101 hydrochloride can be used for the research of ovarian cancer and solid tumors .
    JI-101 hydrochloride
  • HY-179572
    STA-013

    		EGFR Akt Mitochondrial Metabolism Metabolic Disease
    STA-013 is a EphB tyrosine kinase inhibitor. STA-013 shows promising potency against EphB1 (IC50 = 0.69 µM), EphB2 (IC50 = 1.73 µM), and EphB4 (IC50 = 1.02 µM) tyrosine kinases. STA-013 results a inhibition of the EphB phosphorylated signal, coupled with increased p-AKT/AKT signaling, to suggest insulin signaling activation. STA-013 inhibits EphB tyrosine kinase by enhancing insulin receptor beta (IRβ) signaling, and decreasing TGF-β levels in the heart. STA-013 can be used for the study of type 2 diabetes and cardiac complications (diabetic cardiomyopathy) .
    STA-013

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