1394837-94-5
Chemical Structure
EphB4-IN-1
- CAS No.: 1394837-94-5
- Formula:C18H18N4O2
- Molecular Weight:322.36
InChIKey: ZQQZSFIPDUAFMC-UHFFFAOYSA-N
SMILES: O=C1C2=C(CCCC2)C3=C(N1C4=CC(O)=CC=C4C)N=CN=C3N
Biological Activity: EphB4-IN-1 is a selective EphB4 tyrosine kinase inhibitor with IC50 values of 0.16-0.30 μM. EphB4-IN-1 binds to the ATP binding site of EphB4 in a DFG-in conformation, forming four stable intermolecular hydrogen bonds. EphB4-IN-1 also inhibits Src, Abl1, Lck, and EGFR kinases. EphB4-IN-1 inhibits EphB4 autophosphorylation. EphB4-IN-1 can be used for the research of cancer, such as non small cell lung cancer[1].
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EphB4-IN-1 | EphB4-IN-1 is a selective EphB4 tyrosine kinase inhibitor with IC50 values of 0.16-0.30 μM. EphB4-IN-1 binds to the ATP binding site of EphB4 in a DFG-in conformation, forming four stable intermolecular hydrogen bonds. EphB4-IN-1 also inhibits Src, Abl1, Lck, and EGFR kinases. EphB4-IN-1 inhibits EphB4 autophosphorylation. EphB4-IN-1 can be used for the research of cancer, such as non small cell lung cancer. | |||||||||||||||||||||
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Keywords
